| Catalogue number: | PA 18 1081041 |
| Chemical name: | Isopropyl ((S)-(4-nitrophenoxy)(phenoxy)phosphoryl)-L-alaninate |
CAS Number: |
1256490-31-9 |
| Category: | impurities,metabolites,pharmaceutical standards,intermediates,Fine Chemicals |
| Synonyms: | L-Alanine, N-[(S)-(4-nitrophenoxy)phenoxyphosphinyl]-, 1-methylethyl ester; N-[(S)-(4-Nitrophenoxy)phenoxyphosphinyl]-L-alanine 1-methylethyl Ester; |
| Molecular form: | C18H21N2O7P |
| Appearance: | Pale Yellow Oil |
| Mol. Weight: | 408.35 |
| Storage: | 2-8°C Refrigerator |
| Shipping Conditions: | Ambient |
| Applications: | N-[(S)-(4-Nitrophenoxy)phenoxy-2,3,4,5,6-d5-phosphinyl]-L-Alanine-d5 1-Methylethyl Ester is an intermediate in synthesizing PSI-7977-D5, an isotope labelled analog of PSI-7977. PSI-7977 is a prodrug that is metabolized to the active antiviral agent 2'-deoxy-2'-α-fluoro-β-C-methyluridine-5'-monophosphate and is currently being investigated in phase 3 clinical trials for the treatment of hepatitis C. Studies have profiled PSI-7977 as a nucleotide inhibitor of hepatitis C virus, exerting selective inhibitory effects towards HCV NS5B polymerase. |
Isopropyl ((S)-(4-nitrophenoxy)(phenoxy)phosphoryl)-L-alaninate
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