| Catalogue number: | PA 04 3190000 |
| Chemical name: | Duocarmycin SA |
CAS Number: |
130288-24-3 |
| Category: | Fine Chemicals,pharmaceutical standards,intermediates,Antibody Drug Conjugate |
| Synonyms: | Cyclopropa[c]pyrrolo[3,2-e]indole-6-carboxylic acid, 1,2,4,5,8,8a-hexahydro-4-oxo-2-[(5,6,7-trimethoxy-1H-indol-2-yl)carbonyl]-, methyl ester, (7bR,8aS)-; Cyclopropa[c]pyrrolo[3,2-e]indole-6-carboxylic acid, 1,2,4,5,8,8a-hexahydro-4-oxo-2-[(5,6,7-trimethoxy-1H-indol-2-yl)carbonyl]-, methyl ester, (7bR)-; (+)-Duocarmycin SA; Antibiotic DC 113; methyl (7bR,8aS)-4-oxo-2-(5,6,7-trimethoxy-1H-indole-2-carbonyl)-1,2,4,5,8,8a-hexahydrocyclopropa[c]pyrrolo[3,2-e]indole-6-carboxylate; |
| Molecular form: | C25H23N3O7 |
| Appearance: | NA |
| Mol. Weight: | 477.47 |
| Storage: | 2-8°C Refrigerator |
| Shipping Conditions: | Ambient |
| Applications: | Duocarmycin SA is an orally active antitumor antibiotic with an IC50 of 10 pM[1]. Duocarmycin SA is an extremely potent cytotoxic agent capable of inducing a sequence-selective alkylation of duplex DNA. Duocarmycin SA demonstrates synergistic cytotoxicity against glioblastoma multiforme (GBM) cells treated with proton radiation in vitro |
Duocarmycin SA
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