Name: Duocarmycin SA
Brand: Pharmaffliates
Rating: 4.00 (5 reviews)

Catalogue number:	PA 04 3190000
Chemical name:	Duocarmycin SA
CAS Number:	130288-24-3
Category:	Fine Chemicals,pharmaceutical standards,intermediates,Antibody Drug Conjugate
Synonyms:	Cyclopropa[c]pyrrolo[3,2-e]indole-6-carboxylic acid, 1,2,4,5,8,8a-hexahydro-4-oxo-2-[(5,6,7-trimethoxy-1H-indol-2-yl)carbonyl]-, methyl ester, (7bR,8aS)-; Cyclopropa[c]pyrrolo[3,2-e]indole-6-carboxylic acid, 1,2,4,5,8,8a-hexahydro-4-oxo-2-[(5,6,7-trimethoxy-1H-indol-2-yl)carbonyl]-, methyl ester, (7bR)-; (+)-Duocarmycin SA; Antibiotic DC 113; methyl (7bR,8aS)-4-oxo-2-(5,6,7-trimethoxy-1H-indole-2-carbonyl)-1,2,4,5,8,8a-hexahydrocyclopropa[c]pyrrolo[3,2-e]indole-6-carboxylate;
Molecular form:	C₂₅H₂₃N₃O₇
Appearance:	NA
Mol. Weight:	477.47
Storage:	2-8°C Refrigerator
Shipping Conditions:	Ambient
Applications:	Duocarmycin SA is an orally active antitumor antibiotic with an IC50 of 10 pM[1]. Duocarmycin SA is an extremely potent cytotoxic agent capable of inducing a sequence-selective alkylation of duplex DNA. Duocarmycin SA demonstrates synergistic cytotoxicity against glioblastoma multiforme (GBM) cells treated with proton radiation in vitro

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Duocarmycin SA

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