| Catalogue number: | PA 27 0031381 |
| Chemical name: | DC44SMe |
CAS Number: |
1354787-76-0 |
| Category: | miscellaneous compounds,Antibody Drug Conjugate |
| Synonyms: | (S)-1-(chloromethyl)-3-(5-(5-(4-methyl-4-(methyldisulfaneyl)pentanamido)-1H-indole-2-carboxamido)-1H-indole-2-carbonyl)-2,3-dihydro-1H-benzo[e]indol-5-yl dihydrogen phosphate; 1H-Indole-2-carboxamide, N-[2-[[(1S)-1-(chloromethyl)-1,2-dihydro-5-(phosphonooxy)-3H-benz[e]indol-3-yl]carbonyl]-1H-indol-5-yl]-5-[[4-methyl-4-(methyldithio)-1-oxopentyl]amino]-; N-[2-[[(1S)-1-(Chloromethyl)-1,2-dihydro-5-(phosphonooxy)-3H-benz[e]indol-3-yl]carbonyl]-1H-indol-5-yl]-5-[[4-methyl-4-(methyldithio)-1-oxopentyl]amino]-1H-indole-2-carboxamide; |
| Molecular form: | C38H37ClN5O7PS2 |
| Appearance: | NA |
| Mol. Weight: | 806.29 |
| Storage: | 2-8°C Refrigerator |
| Shipping Conditions: | Ambient |
| Applications: | DC44SMe, a phosphate proagent of cytotoxic DNA alkylator DC44, can be used in the synthesis of antibody-drug conjugate (ADC). DC44SMe exhibits IC50s of 2.0 nM, 2.8 nM, and 1.9 nM for Ramos, Namalwa, and HL60/s cancer cells, respectively. DC44SMe can be used for the targeted treatment of cancer |
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