| Catalogue number: | PA 27 0031478 |
| Chemical name: | NODA-GA-NHS ester |
CAS Number: |
1407166-70-4 |
| Category: | miscellaneous compounds,Antibody Drug Conjugate |
| Synonyms: | 2,2'-(7-(1-carboxy-4-((2,5-dioxopyrrolidin-1-yl)oxy)-4-oxobutyl)-1,4,7-triazonane-1,4-diyl)diacetic acid; 1H-1,4,7-Triazonine-1,4,7-triacetic acid, α1-[3-[(2,5-dioxo-1-pyrrolidinyl)oxy]-3-oxopropyl]hexahydro-; Nodaga-nhs; NODAGA NHS ester; |
| Molecular form: | C19H28N4O10 |
| Appearance: | NA |
| Mol. Weight: | 472.45 |
| Storage: | 2-8°C Refrigerator |
| Shipping Conditions: | Ambient |
| Applications: | NODAGA-NHS (NODA-GA-NHS ester) is a [64]Cu chelator and the dissociated form of DOTA-trastuzumab in vivo. NODAGA-NHS was added in 0.1 M borate buffer at a ratio of 5/20/100 and was able to effectively bind trastuzumab (10 mg/mL) (4°C, 20 h). The copper content of the [64]Cu-NODAGA-trastuzumab was up to 80%. After blood was drawn from the caudal vein of mice, [64]Cu-NODAGA-trastuzumab was injected and showed good tumor uptake in mice expressing HER2 tumors, showing good PET imaging tracking ability |
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