| Catalogue number: | PA 27 0031419 |
| Chemical name: | (S,R,S)-MI-1061 |
CAS Number: |
1410738-90-7 |
| Category: | miscellaneous compounds,Antibody Drug Conjugate |
| Synonyms: | 4-((3'S,4'R,5'S)-6''-chloro-4'-(3-chloro-2-fluorophenyl)-2''-oxodispiro[cyclohexane-1,2'-pyrrolidine-3',3''-indoline]-5'-carboxamido)benzoic acid; Benzoic acid, 4-[[[(3′S,4′R,5′S)-6′′-chloro-4′-(3-chloro-2-fluorophenyl)-1′′,2′′-dihydro-2′′-oxodispiro[cyclohexane-1,2′-pyrrolidine-3′,3′′-[3H]indol]-5′-yl]carbonyl]amino]-; 4-[[[(3′S,4′R,5′S)-6′′-Chloro-4′-(3-chloro-2-fluorophenyl)-1′′,2′′-dihydro-2′′-oxodispiro[cyclohexane-1,2′-pyrrolidine-3′,3′′-[3H]indol]-5′-yl]carbonyl]amino]benzoic acid; |
| Molecular form: | C30H26Cl2FN3O4 |
| Appearance: | NA |
| Mol. Weight: | 582.45 |
| Storage: | 2-8°C Refrigerator |
| Shipping Conditions: | Ambient |
| Applications: | (S,R,S)-MI-1061 is the isomer of MI-1061(HY-125858). (S,R,S)-MI-1061 can used to synthesize Antibody-Drug Conjugates (ADCs). MI-1061 is a potent, orally bioavailable, and chemically stable MDM2 (MDM2-p53 interaction) inhibitor (IC50=4.4 nM; Ki=0.16 nM). MI-1061 potently activates p53 and induces apoptosis in the SJSA-1 xenograft tumor tissue in mice. Anti-tumor activity |
(S,R,S)-MI-1061
(S,R,S)-MI-1061
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