| Catalogue number: | PA 06 0961007 |
| Chemical name: | 1-(2-Iodoethyl)-2-octylbenzene |
CAS Number: |
162358-96-5 |
| Category: | intermediates,impurities,metabolites,pharmaceutical standards,Fine Chemicals |
| Synonyms: | 2-Octylphenethyl iodide; |
| Molecular form: | C16H25I |
| Appearance: | NA |
| Mol. Weight: | 344.28 |
| Storage: | 2-8°C Refrigerator |
| Shipping Conditions: | Ambient |
| Applications: | 1-(2-Iodoethyl)-2-octylbenzene is an impurity of Fingloimod (F805000), also known as FTY720. FTY720 is a derivative of ISP-1 (myriocin), a fungal metabolite of the Chinese herb Iscaria sinclarii as well as a structural analogue of Sphingosine. FTY720 is a novel immune modulator that prolongs allograft transplant survival in numberour models by inhibiting lymphocyte emigration from lymphoid organs. FTY720 us reported to be phosphorylated by sphingosine kinase to FTY720-P, which has been shown to potently stimulate GTPgS binding activity in S1P-transfected CHO cells (EC50 = 210 pM, 4.9 nM, 4.3 nM, and 1 nM for S1P1, S1P3, S1P4 and S1P5, respectively). |
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