| Catalogue number: | PA STI 037030 |
| Chemical name: | ENMD 547-d8 |
CAS Number: |
1795025-33-0 |
| Category: | miscellaneous compounds,stable isotopes |
| Synonyms: | 6-Amino-1-[4-(3-methyl-1-oxobutyl)-1-piperazinyl]-1-hexanone-d8 Hydrobromide; 1-(6-Amino-1-oxohexyl)-4-(3-methyl-1-oxobutyl)piperazine-d8 Monohydrobromide; |
| Molecular form: | C15H22D8BrN3O2 |
| Appearance: | N/A |
| Mol. Weight: | 372.37 |
| Storage: | 2-8°C Refrigerator |
| Shipping Conditions: | Ambient |
| Applications: | Labelled ENMD 547, a selective PAR-2 antagonist. Dose dependently inhibits calcium signaling in Lewis lung carcinoma cells stimulated with a soluble peptide PAR-2 agonist or trypsin, but not with a soluble PAR-1 agonist. Does not inhibit platelet aggregation stimulated by thrombin suggesting that it does not inhibit PAR-3 or PAR-4 signaling. Reduces TNF-a and IL-1β production from rheumatoid arthritis synovial primary cell culture and reduces joint swelling in a carageenan/kaloin-injected mouse model. |
| BTM: | NA |
ENMD 547-d8
ENMD 547-d8
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