| Catalogue number: | PA STI 052490 |
| Chemical name: | iCRT-14-d5 |
CAS Number: |
1795144-12-5 |
| Category: | miscellaneous compounds |
| Synonyms: | 5-[[2,5-Dimethyl-1-(3-pyridinyl)-1H-pyrrol-3-yl]methylene]-3-(phenyl-d5)-2,4-thiazolidinedione; iCRT 14-d5; iCRT14-d5; |
| Molecular form: | C21H12D5N3O2S |
| Appearance: | NA |
| Mol. Weight: | 380.47 |
| Storage: | 2-8°C Refrigerator |
| Shipping Conditions: | Ambient |
| Applications: | A labelled potent inhibitor of β-catenin-responsive transcription (CRT) (IC50 = 40.3 nM in assays of Wnt pathway activity). Studies suggest that it may directly influence the interaction between β-catenin and TCF4. It induces marked G0/G1 cell cycle arrest in HCT-116 and HT29 cell lines. |
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