| Catalogue number: | PA 27 0032207 |
| Chemical name: | Methyltetrazine-DBCO |
CAS Number: |
1802238-48-7 |
| Category: | miscellaneous compounds,Antibody Drug Conjugate |
| Synonyms: | 2-Propanesulfonic acid, 3-[[4-(11,12-didehydrodibenz[b,f]azocin-5(6H)-yl)-1,4-dioxobutyl]amino]-1-[[3-[4-(6-methyl-1,2,4,5-tetrazin-3-yl)phenoxy]propyl]amino]-1-oxo; 3-[[4-(11,12-Didehydrodibenz[b,f]azocin-5(6H)-yl)-1,4-dioxobutyl]amino]-1-[[3-[4-(6-methyl-1,2,4,5-tetrazin-3-yl)phenoxy]propyl]amino]-1-oxo-2-propanesulfonic Acid; |
| Molecular form: | C34H33N7O7S |
| Appearance: | NA |
| Mol. Weight: | 683.74 |
| Storage: | 2-8°C Refrigerator |
| Shipping Conditions: | Ambient |
| Applications: | Methyltetrazine-DBCO is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[1]. Methyltetrazine-DBCO is a click chemistry reagent, it contains a DBCO group that can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing Azide groups. Methyltetrazine-DBCO also contains a Tetrazine group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing TCO groups. |
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