Catalogue number: | PA PEP 002861 |
Chemical name: | Azido-PEG4-Val-Cit-PAB-MMAE |
CAS Number: |
1869126-64-6 |
Category: | peptides,Antibody Drug Conjugate |
Synonyms: | 4-((17S,20S)-1-Azido-17-isopropyl-15,18-dioxo-20-(3-ureidopropyl)-3,6,9,12-tetraoxa-16,19-diazahenicosan-21-amido)benzyl ((S)-1-(((S)-1-(((3R,4S,5S)-1-((S)-2-((1R,2R)-3-(((1S,2R)-1-hydroxy-1-phenylpropan-2-yl)amino)-1-methoxy-2-methyl-3-oxopropyl)pyrrolidin-1-yl)-3-methoxy-5-methyl-1-oxoheptan-4-yl)(methyl)amino)-3-methyl-1-oxobutan-2-yl)amino)-3-methyl-1-oxobutan-2-yl)(methyl)carbamate; |
Molecular form: | C69H113N13O17 |
Appearance: | Solid |
Mol. Weight: | 1396.74 |
Storage: | 2-8°C Refrigerator |
Shipping Conditions: | Ambient |
Applications: | Azido-PEG4-Val-Cit-PAB-MMAE is a agent-linker conjugate for ADC by using the anti-mitotic agent, monomethyl auristatin E (MMAE, a tubulin inhibitor), linked via the cleavable linker Azido-PEG4-Val-Cit-PAB-OH[1]. Azido-PEG4-Val-Cit-PAB-MMAE is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups. |
Azido-PEG4-Val-Cit-PAB-MMAE
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