| Catalogue number: | PA 20 3170000 |
| Chemical name: | Tipifarnib |
CAS Number: |
192185-72-1 |
| Category: | impurities,metabolites,pharmaceutical standards,intermediates,Fine Chemicals |
| Synonyms: | R)-6-(Amino(4-chlorophenyl)(1-methyl-1H-imidazol-5-yl)methyl)-4-(3-chlorophenyl)-1-methylquinolin-2(1H)-one; 6-[(R)-Amino(4-chlorophenyl)(1-methyl-1H-imidazol-5-yl)methyl]-4-(3-chlorophenyl)-1-methyl-2(1H)-quinolinone; Zarnestra; |
| Molecular form: | C27H22Cl2N4O |
| Appearance: | Off-White to Pale Beige Solid |
| Mol. Weight: | 489.4 |
| Storage: | 2-8°C Refrigerator |
| Shipping Conditions: | Ambient |
| Applications: | A farnesyltransferase inhibitor. Sensitizes human multiple myeloma cell to proteasome inhibition by blocking degradation of bortezomib-induced aggresomes. Also shown to inhibit the growth of myeloid leukemia cell lines and primary leukemia cells by inducing apoptosis and cell-cycle blockage when combined with rapamycin. |
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