| Catalogue number: | PA PEP 004616 |
| Chemical name: | Gamma-Amanitin |
CAS Number: |
21150-23-2 |
| Category: | peptides,Antibody Drug Conjugate |
| Synonyms: | γ-Amanitin; α-Amanitin, 3-[(4S)-4-hydroxy-L-isoleucine]-; α-Amanitin, 3-[(4S)-4-hydroxy-L-isoleucine]-; 9,18-(Iminoethaniminoethaniminoethaniminomethano)pyrrolo[1′,2′:8,9][1,5,8,11,14]thiatetraazacyclooctadecino[18,17-b]indole, cyclic peptide deriv; α-Amanitin, 3-[(S)-4-hydroxy-L-isoleucine]-; Cyclo[L-asparaginyl-4-hydroxy-L-prolyl-(S)-4-hydroxy-L-isoleucyl-6-hydroxy-2-mercapto-L-tryptophylglycyl-L-isoleucylglycyl-L-cysteinyl] cyclic (4→8)-sulfide (R)-S-oxide; |
| Molecular form: | C39H54N10O13S |
| Appearance: | NA |
| Mol. Weight: | 902.98 |
| Storage: | 2-8°C Refrigerator |
| Shipping Conditions: | Ambient |
| Applications: | γ-Amanitin an ADC cytotoxin and isolated from the mushroom. γ-Amanitin inhibits RNA polymerase II and disrupts synthesis of mRNA. γ-Amanitin shows similar effects to α-Amanitin and β-Amanitin. γ-Amanitin competitively binds to monoclonal antibody (mAb), with an IC50 of 163.1 ng/mL. γ-Amanitin is toxic to a variety of cells |
Gamma-Amanitin
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