| Catalogue number: | PA 27 0035419 |
| Chemical name: | 4-(4-(3-(2,5-Dioxo-2,5-dihydro-1H-pyrrol-1-yl)propanoyl)piperazin-1-yl)-N-(2-fluoro-4-((1S,2S)-2-(pyridin-3-yl)cyclopropane-1-carboxamido)benzyl)benzamide |
CAS Number: |
2241014-82-2 |
| Category: | miscellaneous compounds,Antibody Drug Conjugate |
| Synonyms: | Benzamide, 4-[4-[3-(2,5-dihydro-2,5-dioxo-1H-pyrrol-1-yl)-1-oxopropyl]-1-piperazinyl]-N-[[2-fluoro-4-[[[(1S,2S)-2-(3-pyridinyl)cyclopropyl]carbonyl]amino]phenyl]methyl]-; 4-[4-[3-(2,5-Dihydro-2,5-dioxo-1H-pyrrol-1-yl)-1-oxopropyl]-1-piperazinyl]-N-[[2-fluoro-4-[[[(1S,2S)-2-(3-pyridinyl)cyclopropyl]carbonyl]amino]phenyl]methyl]benzamide; NAMPT inhibitor-linker 2; |
| Molecular form: | C34H33FN6O5 |
| Appearance: | Solid |
| Mol. Weight: | 624.67 |
| Storage: | 2-8°C Refrigerator |
| Shipping Conditions: | Ambient |
| Applications: | NAMPT inhibitor-linker 2 is a agent-linker conjugates for ADC, composed of an NAMPT inhibitor as a payload, and a linker. ADC-4 consists of an NAMPT inhibitor-linker 2 and an anti-c-Kit monoclonal antibody, exihibits potent activity against c-Kit expressing cell lines such as GIST-T1 and NCI-H526, with IC50s of <7 pM and 40 pM, respectively. |
4-(4-(3-(2,5-Dioxo-2,5-dihydro-1H-pyrrol-1-yl)propanoyl)piperazin-1-yl)-N-(2-fluoro-4-((1S,2S)-2-(pyridin-3-yl)cyclopropane-1-carboxamido)benzyl)benzamide
4-(4-(3-(2,5-Dioxo-2,5-dihydro-1H-pyrrol-1-yl)propanoyl)piperazin-1-yl)-N-(2-fluoro-4-((1S,2S)-2-(pyridin-3-yl)cyclopropane-1-carboxamido)benzyl)benzamide
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