| Catalogue number: | PA 27 0035420 |
| Chemical name: | β-Glucuronide-dPBD-PEG5-NH2 |
CAS Number: |
2246363-68-6 |
| Category: | miscellaneous compounds,Antibody Drug Conjugate |
| Synonyms: | (2S,3S,4S,5R,6S)-6-(2-((17-(Aminooxy)-3,6,9,12,15-pentaoxaheptadecyl)carbamoyl)-4-((((11aS)-8-((5-(((11aS)-10-(((4-(((2S,3R,4S,5S,6S)-6-carboxy-3,4,5-trihydroxytetrahydro-2H-pyran-2-yl)oxy)-3-((2-methoxyethyl)carbamoyl)benzyl)oxy)carbonyl)-11-hydroxy-7-methoxy-2-methylene-5-oxo-2,3,5,10,11,11a-hexahydro-1H-benzo[e]pyrrolo[1,2-a][1,4]diazepin-8-yl)oxy)pentyl)oxy)-11-hydroxy-7-methoxy-2-methylene-5-oxo-2,3,5,10,11,11a-hexahydro-1H-benzo[e]pyrrolo[1,2-a][1,4]diazepine-10-carbonyl)oxy)methyl)phenoxy)-3,4,5-trihydroxytetrahydro-2H-pyran-2-carboxylic Acid; |
| Molecular form: | C78H101N7O35 |
| Appearance: | NA |
| Mol. Weight: | 1696.68 |
| Storage: | 2-8°C Refrigerator |
| Shipping Conditions: | Ambient |
| Applications: | β-Glucuronide-dPBD-PEG5-NH2 is the β-glucuronide-linked pyrrolobenzodiazepine dimer, which binds to the prenylated antibody for synthesis of antibody-drug conjugate (ADC) cIRCR201-dPBD. β-glucuronide-linkage as a cleavable linker. β-Glucuronide-dPBD-PEG5-NH2, as a proagent of cIRCR201-dPBD, reduces side effects. β-Glucuronide-dPBD-PEG5-NH2 can induce apoptosis and arrest cell cycle. β-Glucuronide-dPBD-PEG5-NH2 has antitumor activity |
β-Glucuronide-dPBD-PEG5-NH2
β-Glucuronide-dPBD-PEG5-NH2
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