| Catalogue number: | PA 27 0032713 |
| Chemical name: | 4-((29S,32S)-29-benzyl-32-(4-((Tert-butoxycarbonyl)amino)butyl)-1-(4-((6-(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)hexanamido)methyl)-1H-1,2,3-triazol-1-yl)-27,30-dioxo-3,6,9,12,15,18,21,24-octaoxa-28,31-diazatritriacontan-33-amido)benzyl (3-hydroxy-2-oxopropyl) ethane-1,2-diylbis(methylcarbamate); |
CAS Number: |
2270986-66-6 |
| Category: | miscellaneous compounds,Antibody Drug Conjugate |
| Synonyms: | CL2 Linker; |
| Molecular form: | C68H103N11O22 |
| Appearance: | NA |
| Mol. Weight: | 1426.63 |
| Storage: | 2-8°C Refrigerator |
| Shipping Conditions: | Ambient |
| Applications: | CL2 Linker is a cleavableADC linker. CL2-SN-38 and CL2A-SN-38 are equivalent in agent substitution (~6), cell binding (Kd ~1.2 nM), cytotoxicity (IC50 ~2.2 nM), and serum stability in vitro (t1/2 ~20 hours) |
4-((29S,32S)-29-benzyl-32-(4-((Tert-butoxycarbonyl)amino)butyl)-1-(4-((6-(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)hexanamido)methyl)-1H-1,2,3-triazol-1-yl)-27,30-dioxo-3,6,9,12,15,18,21,24-octaoxa-28,31-diazatritriacontan-33-amido)benzyl (3-hydroxy-2-oxopropyl) ethane-1,2-diylbis(methylcarbamate);
4-((29S,32S)-29-benzyl-32-(4-((Tert-butoxycarbonyl)amino)butyl)-1-(4-((6-(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)hexanamido)methyl)-1H-1,2,3-triazol-1-yl)-27,30-dioxo-3,6,9,12,15,18,21,24-octaoxa-28,31-diazatritriacontan-33-amido)benzyl (3-hydroxy-2-oxopropyl) ethane-1,2-diylbis(methylcarbamate);
Enquire for 4-((29S,32S)-29-benzyl-32-(4-((Tert-butoxycarbonyl)amino)butyl)-1-(4-((6-(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)hexanamido)methyl)-1H-1,2,3-triazol-1-yl)-27,30-dioxo-3,6,9,12,15,18,21,24-octaoxa-28,31-diazatritriacontan-33-amido)benzyl (3-hydroxy-2-oxopropyl) ethane-1,2-diylbis(methylcarbamate);
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