Catalogue number: | PA PEP 003155 |
Chemical name: | Taltobulin trifluoroacetate |
CAS Number: |
228266-41-9 |
Similar Products: | |
Category: | peptides,Antibody Drug Conjugate |
Synonyms: | (S,E)-2,5-Dimethyl-4-((S)-N,3,3-trimethyl-2-((S)-3-methyl-2-(methylamino)-3-phenylbutanamido)butanamido)hex-2-enoic acid--2,2,2-trifluoroacetic acid (1/1); L-Valinamide, N,β,β-trimethyl-L-phenylalanyl-N-[(1S,2E)-3-carboxy-1-(1-methylethyl)-2-butenyl]-N,3-dimethyl-, mono(trifluoroacetate); |
Molecular form: | C29H44F3N3O6 |
Appearance: | Solid |
Mol. Weight: | 587.68 |
Storage: | 2-8°C Refrigerator |
Shipping Conditions: | Ambient |
Applications: | Taltobulin trifluoroacetate (HTI-286 trifluoroacetate), a synthetic analogue of the tripeptide hemiasterlin, is a potent antimicrotubule agent that circumvents P-glycoprotein-mediated resistance in vitro and in vivo. Taltobulin trifluoroacetate inhibits the polymerization of purified tubulin, disrupts microtubule organization in cells, and induces mitotic arrest, as well as apoptosis |
Taltobulin trifluoroacetate
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