| Catalogue number: | PA 27 0032913 |
| Chemical name: | EB-PSMA-617 |
CAS Number: |
2375590-67-1 |
| Category: | miscellaneous compounds,Antibody Drug Conjugate |
| Synonyms: | (((1S)-5-((2S)-2-((1r,4S)-4-((2-((1-(3-(((S)-6-((4'-((8-Amino-1-hydroxy-5,7-disulfonaphthalen-2-yl)diazenyl)-3,3'-dimethyl-[1,1'-biphenyl]-4-yl)amino)-6-oxo-5-(2-(4,7,10-tris(carboxymethyl)-1,4,7,10-tetraazacyclododecan-1-yl)acetamido)hexyl)amino)-3-oxopropyl)-2,5-dioxopyrrolidin-3-yl)thio)acetamido)methyl)cyclohexane-1-carboxamido)-3-(naphthalen-2-yl)propanamido)-1-carboxypentyl)carbamoyl)-L-glutamic Acid; |
| Molecular form: | C88H112N16O28S3 |
| Appearance: | Solid |
| Mol. Weight: | 1938.13 |
| Storage: | 2-8°C Refrigerator |
| Shipping Conditions: | Ambient |
| Applications: | EB-PSMA-617 is a modified form of PSMA-617 that has enhanced pharmacokinetic properties by conjugating it to Evans Blue (EB) to extend its circulation half-life to improve prostate tumor uptake and radiotherapy efficacy. In preclinical studies using PC3-PIP-loaded mice, EB-PSMA-617 demonstrated prolonged blood half-life, increased accumulation in PSMA-positive tumors, and successful tumor elimination with lower radioactivity |
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EB-PSMA-617
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