| Catalogue number: | PA PEP 003143 |
| Chemical name: | GB-6 |
CAS Number: |
2413262-74-3 |
| Category: | peptides,Antibody Drug Conjugate |
| Synonyms: | (S)-N1-((2S,8S,15S)-2-((1H-Imidazol-5-yl)methyl)-1-amino-16-(5-hydroxy-1H-indol-3-yl)-1,4,7,10,14-pentaoxo-8-propyl-3,6,9,13-tetraazahexadecan-15-yl)-2-aminopentanediamide; |
| Molecular form: | C32H45N11O8 |
| Appearance: | NA |
| Mol. Weight: | 711.78 |
| Storage: | 2-8°C Refrigerator |
| Shipping Conditions: | Ambient |
| Applications: | GB-6 is a short linear peptide that targets the gastrin releasing peptide receptor (GRPR). GRPR is overexpressed in pancreatic cancer. Based on the tumor selectivity and tumor-specific accumulation properties of GB-6, GB-6 labeled with near infrared (NIR) fluorescent dyes or radionuclide netium-99m (99mTc) can be used as a high-contrast imaging probe. GB-6 has excellent in vivo stability, with tumor to pancreatic and intestinal fluorescence signal ratios of 5.2 and 6.3, respectively, in SW199 0 subcutaneous xenograft models. GB-6 can rapidly target tumors and accurately delineate tumor boundaries, which has broad application prospects |
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