Name: Fmoc-L-Asn(EDA-N3)-OH
Brand: Pharmaffliates
Rating: 4.00 (5 reviews)

Catalogue number:	PA 27 0033107
Chemical name:	Fmoc-L-Asn(EDA-N3)-OH
CAS Number:	2616562-74-2
Category:	miscellaneous compounds,Antibody Drug Conjugate
Synonyms:	N-(2-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)ethyl)-N-(2-azidoacetyl)glycine; L-Asparagine, N-(2-azidoethyl)-N2-[(9H-fluoren-9-ylmethoxy)carbonyl]-; N-(2-Azidoethyl)-N2-[(9H-fluoren-9-ylmethoxy)carbonyl]-L-asparagine;
Molecular form:	C₂₁H₂₁N₅O₅
Appearance:	NA
Mol. Weight:	423.43
Storage:	2-8°C Refrigerator
Shipping Conditions:	Ambient
Applications:	Fmoc-L-Asn(EDA-N3)-OH is a click chemistry reagent containing an azide group. This building block is reported in literature for the modification of Amanitin via Click Chemistry. Alpha-Amanitin is the deadliest member of the amatoxin peptide family produced by the death-cap mushroom A. phalloides. It is an orally available, rigid, bicyclic octapeptide and one of the most lethal known natural products (LD50 = 50-100 μg/kg) acting as highly selective allosteric inhibitor of the RNA polymerase II[1]. It contains an azide group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing alkyne groups. It can also undergo ring strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing DBCO or BCN groups

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Fmoc-L-Asn(EDA-N3)-OH

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