| Catalogue number: | PA 27 0017303 |
| Chemical name: | SANT-1 |
CAS Number: |
304909-07-7 |
| Category: | miscellaneous compounds |
| Synonyms: | (E)-N-(4-Benzylpiperazin-1-yl)-1-(3,5-dimethyl-1-phenyl-1H-pyrazol-4-yl)methanimine; |
| Molecular form: | C23H27N5 |
| Appearance: | Off-White to Pale Yellow Solid |
| Mol. Weight: | 373.5 |
| Storage: | 2-8°C Refrigerator |
| Shipping Conditions: | Ambient |
| Applications: | A potent antagonist of the sonic hedgehog (Shh) signaling pathway (IC50=20nm inShh-LIGHT2 assay an d in Ptch1-/- cells) that acts by binding to smoothened (Smo: KD=1.2 nM), a distant relative of G protein-coupled receptors. In contrast to cyclopamine, SNAT-1 inhibits the activities of both wild type and oncogenic Smo with equal potency (IC50=30nm in SmoA1-LIGHT2 assay). |
| BTM: | NA |
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