| Catalogue number: | PA 27 0035817 |
| Chemical name: | DOTA-GA(tBu)4 |
CAS Number: |
306776-79-4 |
| Category: | miscellaneous compounds,Antibody Drug Conjugate |
| Synonyms: | 5-(tert-butoxy)-5-oxo-4-(4,7,10-tris(2-(tert-butoxy)-2-oxoethyl)-1,4,7,10-tetraazacyclododecan-1-yl)pentanoic Acid; 1,4,7,10-Tetrakis(1,1-dimethylethyl) α-(2-carboxyethyl)-1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetate; 5-(tert-Butoxy)-5-oxo-4-[4,7,10-tris[2-(tert-butoxy)-2-oxoethyl]-1,4,7,10-tetraazacyclododecan-1-yl]pentanoic acid; DOTAGA-tetra(t-Bu ester); |
| Molecular form: | C35H64N4O10 |
| Appearance: | Solid |
| Mol. Weight: | 700.92 |
| Storage: | 2-8°C Refrigerator |
| Shipping Conditions: | Ambient |
| Applications: | DOTA-GA(tBu)4 stabilizes the attachment of radiometals to ligands. DOTA-GA(tBu)4 improves the biodistribution of radiolabeled second-generation Affibody molecules by increasing their net negative charge and reducing hepatic uptake, leading to enhanced tumor-to-blood and tumor-to-liver ratios. DOTA-GA(tBu)4 targets HER2>-expressing breast and gastrointestinal cancer |
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DOTA-GA(tBu)4
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