| Catalogue number: | PA 27 0016990 |
| Chemical name: | 4-Benzyl-2-methyl-1,2,4-thiadiazolidine-3,5-dione |
CAS Number: |
327036-89-5 |
| Category: | miscellaneous compounds |
| Synonyms: | 4-Benzyl-2-methyl-1,2,4-thiadiazolidine-3,5-dione; |
| Molecular form: | C10H10N2O2S |
| Appearance: | White Solid |
| Mol. Weight: | 222.26 |
| Storage: | 2-8°C Refrigerator |
| Shipping Conditions: | Ambient |
| Applications: | Glycogen Synthase Kinase-3ß is a highly conserved ubiquitously expressed serine/threonine protein kinase involved in signal transduction cascades of multiple cellular processes. TDZD-8 is a thiadiazolidinone (TDZD) analogue that acts as a highly selective, non-ATP competitive inhibitor of GSK-3ß ( IC50 =2nM). Binds to the active site of GSK-3ß. Does not significantly affect the activities of Cdk-1/cyclin B, CK-II, PKA, and PKC (IC50 >100nM). |
4-Benzyl-2-methyl-1,2,4-thiadiazolidine-3,5-dione
4-Benzyl-2-methyl-1,2,4-thiadiazolidine-3,5-dione
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