| Catalogue number: | PA 03 0741011 |
| Chemical name: | 1-Demethylcolchicine |
CAS Number: |
3464-68-4 |
| Category: | impurities,metabolites,pharmaceutical standards,intermediates,Fine Chemicals |
| Synonyms: | (S)-N-(1-Hydroxy-2,3,10-trimethoxy-9-oxo-5,6,7,9-tetrahydrobenzo[a]heptalen-7-yl)acetamide; Acetamide, N-[(7S)-5,6,7,9-tetrahydro-1-hydroxy-2,3,10-trimethoxy-9-oxobenzo[a]heptalen-7-yl]; Acetamide, N-(5,6,7,9-tetrahydro-1-hydroxy-2,3,10-trimethoxy-9-oxobenzo[a]heptalen-7-yl)-, (S); Benzo[a]heptalene, acetamide deriv; Colchicine, 1-demethyl; N-[(7S)-5,6,7,9-Tetrahydro-1-hydroxy-2,3,10-trimethoxy-9-oxobenzo[a]heptalen-7-yl]acetamide; (-)-1-Demethylcolchicine; Colchicine, demethyl-; O1-Demethylcolchicine; |
| Molecular form: | C21H23NO6 |
| Appearance: | NA |
| Mol. Weight: | 385.42 |
| Storage: | 2-8°C Refrigerator |
| Shipping Conditions: | Ambient |
| Applications: | 1-Demethylcolchicine is a derivative of Colchicine an antimitotic agent that disrupts microtubles by binding to tubulin and preventing its polymerization. Stimulates the intrinsic GTPase activity of tubulin. Induces apoptosis in several normal and tumor cell lines and activates the JNK/SAPK signaling pathway. |
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