| Catalogue number: | PA 27 0016988 |
| Chemical name: | Aloisine A RP107 |
CAS Number: |
496864-16-5 |
| Category: | miscellaneous compounds |
| Synonyms: | 4-(7-Butyl-5H-pyrrolo[2,3-b]pyrazin-6-yl)phenol; |
| Molecular form: | C16H17N3O |
| Appearance: | Light Orangish Yellow solid |
| Mol. Weight: | 267.33 |
| Storage: | 2-8°C Refrigerator |
| Shipping Conditions: | Ambient |
| Applications: | A cell-permeable pyrrolo-pyrazine compound that acts as a potent, selective, reversible, and ATP-competitive inhibitor of cyclin dependent kinases (Cdks: IC50 =150nM, 120 nM, 400 nM and 200 nM for Cdk1/cyclin B, Cdk2/cyclin A, Cdk2/cyclin E, and Cdk5/p25, respectively). Also inhibits the activity of clycogen synthase kinase-3 (GSK-3,:(IC50 =500 nM and 1.5 uM for GSK-3a, GSK-3ß, respectively), and c-Jun N-terminal kinase (JNK: IC50 approx. 3-10uM). |
| BTM: | NA |
Aloisine A RP107
Aloisine A RP107
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