| Catalogue number: | PA 47 0391009 |
| Chemical name: | Teriflunomide-3-isomer |
CAS Number: |
62004-05-1 |
| Category: | intermediates,impurities,pharmaceutical standards,Fine Chemicals,metabolites,tyrosine kinase inhibitors |
| Synonyms: | 2-Cyano-3-hydroxy-N-[3-(trifluoromethyl)phenyl]-2-butenamide; 2-Butenamide, 2-cyano-3-hydroxy-N-[3-(trifluoromethyl)phenyl]-; |
| Molecular form: | C12H9F3N2O2 |
| Appearance: | NA |
| Mol. Weight: | 270.21 |
| Storage: | 2-8°C Refrigerator |
| Shipping Conditions: | Ambient |
| Applications: | 2-Cyano-3-hydroxy-N-[3-(trifluoromethyl)phenyl]-2-butenamide is a derivative of Leflunomide which is an immunosuppressive. Inhibits T and B cell proliferation. Activity is attributed mainly to its metabolite, a malononitrile derivative, which is beleived to inhibit dihydroorotate dehydrogenase as well as several protein tyrosine kinases. Therapeutically as a antirheumatic (Merck Index). This compound is suitable for dihydroorotate dehydrogenase (DHODH) related research. |
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