| Catalogue number: | PA 27 0036215 |
| Chemical name: | 2,5-Dioxopyrrolidin-1-yl 3-(pyridin-2-yldisulfaneyl)propanoate |
CAS Number: |
68181-17-9 |
| Category: | miscellaneous compounds,Antibody Drug Conjugate |
| Synonyms: | Propanoic acid, 3-(2-pyridinyldithio)-, 2,5-dioxo-1-pyrrolidinyl Ester; (2,5-Dioxopyrrolidin-1-yl) 3-(pyridin-2-yldisulfanyl)propanoate; Succinimidyl 3-[(2-pyridyl)dithio]propionate; SPDP; |
| Molecular form: | C12H12N2O4S2 |
| Appearance: | Solid |
| Mol. Weight: | 312.36 |
| Storage: | 2-8°C Refrigerator |
| Shipping Conditions: | Ambient |
| Applications: | SPDP (SPDP Crosslinker) is a short-chain crosslinker for amine-to-sulfhydryl conjugation via NHS-ester and pyridyldithiol reactive groups that form cleavable (reducible) disulfide bonds with cysteine sulfhydryls. It is a glutathione cleavable ADC linker used for the antibody-drug conjugates (ADCs) |
2,5-Dioxopyrrolidin-1-yl 3-(pyridin-2-yldisulfaneyl)propanoate
2,5-Dioxopyrrolidin-1-yl 3-(pyridin-2-yldisulfaneyl)propanoate
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