| Catalogue number: | PA 27 0035388 |
| Chemical name: | Tubulysin H |
CAS Number: |
799822-09-6 |
| Category: | miscellaneous compounds,Antibody Drug Conjugate |
| Synonyms: | (2S,4R)-4-(2-((1R,3R)-1-Acetoxy-3-((2S,3S)-N-(acetoxymethyl)-3-methyl-2-((R)-1-methylpiperidine-2-carboxamido)pentanamido)-4-methylpentyl)thiazole-4-carboxamido)-2-methyl-5-phenylpentanoic acid; Benzenepentanoic acid, γ-[[[2-[(1R,3R)-1-(acetyloxy)-3-[[(acetyloxy)methyl][(2S,3S)-3-methyl-2-[[[(2R)-1-methyl-2-piperidinyl]carbonyl]amino]-1-oxopentyl]amino]-4-methylpentyl]-4-thiazolyl]carbonyl]amino]-α-methyl-, (αS,γR)-; (αS,γR)-γ-[[[2-[(1R,3R)-1-(Acetyloxy)-3-[[(acetyloxy)methyl][(2S,3S)-3-methyl-2-[[[(2R)-1-methyl-2-piperidinyl]carbonyl]amino]-1-oxopentyl]amino]-4-methylpentyl]-4-thiazolyl]carbonyl]amino]-α-methylbenzenepentanoic acid; |
| Molecular form: | C40H59N5O9S |
| Appearance: | NA |
| Mol. Weight: | 786 |
| Storage: | 2-8°C Refrigerator |
| Shipping Conditions: | Ambient |
| Applications: | Tubulysin H is a highly cytotoxic anti-microtubule toxin (anti-microtubule toxins) that is synthesized as an ADC cytotoxin (ADC Cytotoxin). Tubulysin H can be isolated from the myxobacteria Archangium geophyra and Angiococcus disciformis. Tubulysin H displays extremely potent cytotoxic activity in mammalian cells, including multidrug-resistant cell lines, with IC50 values in the low nanomolar range. Tubulysin H inhibits microtubule/tubulin polymerization and leads to cell cycle arrest and apoptosis |
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