| Catalogue number: | PA 12 0491004 |
| Chemical name: | (S)-1-(Chloromethyl)-3-(5-(4-((S)-2-((S)-2-((2-(4-(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)butanamido)ethyl)amino)-3-methylbutanamido)-5-ureidopentanamido)benzamido)-1H-indole-2-carbonyl)-2,3-dihydro-1H-benzo[e]indol-5-yl 4-methylpiperazine-1-carboxylate |
CAS Number: |
932744-62-2 |
| Category: | pharmaceutical standards,aliphatics,Fine Chemicals,amines,Intermediates,Antibody Drug Conjugate |
| Synonyms: | L-Ornithinamide, N-[2-[[4-(2,5-dihydro-2,5-dioxo-1H-pyrrol-1-yl)-1-oxobutyl]amino]ethyl]-L-valyl-N5-(aminocarbonyl)-N-[4-[[[2-[[(1S)-1-(chloromethyl)-1,2-dihydro-5-[[(4-methyl-1-piperazinyl)carbonyl]oxy]-3H-benz[e]indol-3-yl]carbonyl]-1H-indol-5-yl]amino]carbonyl]phenyl]-; N-[2-[[4-(2,5-Dihydro-2,5-dioxo-1H-pyrrol-1-yl)-1-oxobutyl]amino]ethyl]-L-valyl-N5-(aminocarbonyl)-N-[4-[[[2-[[(1S)-1-(chloromethyl)-1,2-dihydro-5-[[(4-methyl-1-piperazinyl)carbonyl]oxy]-3H-benz[e]indol-3-yl]carbonyl]-1H-indol-5-yl]amino]carbonyl]phenyl]-L-ornithinamide; |
| Molecular form: | C56H65ClN12O10 |
| Appearance: | NA |
| Mol. Weight: | 1101.66 |
| Storage: | 2-8°C Refrigerator |
| Shipping Conditions: | Ambient |
| Applications: | MB-VC-MGBA is a agent-linker conjugate for ADC with potent antitumor activity by using MGBA (minor-groove-binding DNA-alkylating agent), linked via the ADC linker MB-VC |
(S)-1-(Chloromethyl)-3-(5-(4-((S)-2-((S)-2-((2-(4-(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)butanamido)ethyl)amino)-3-methylbutanamido)-5-ureidopentanamido)benzamido)-1H-indole-2-carbonyl)-2,3-dihydro-1H-benzo[e]indol-5-yl 4-methylpiperazine-1-carboxylate
In House Impurity(S)-1-(Chloromethyl)-3-(5-(4-((S)-2-((S)-2-((2-(4-(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)butanamido)ethyl)amino)-3-methylbutanamido)-5-ureidopentanamido)benzamido)-1H-indole-2-carbonyl)-2,3-dihydro-1H-benzo[e]indol-5-yl 4-methylpiperazine-1-carboxylate
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