| Catalogue number: | PA STI 072200 |
| Chemical name: | PF-3644022-d4 |
CAS Number: |
NA |
| Category: | miscellaneous compounds,stable isotopes |
| Synonyms: | (10R)-9,10,11,12-Tetrahydro-10-methyl-3-(6-methyl-3-pyridinyl)-8H-[1,4]diazepino[5',6':4,5]thieno[3,2-f]quinolin-8-one-d4; |
| Molecular form: | C21H14D4N4OS |
| Appearance: | NA |
| Mol. Weight: | 378.48 |
| Storage: | 2-8°C Refrigerator |
| Shipping Conditions: | Ambient |
| Applications: | Labelled analogue of PF-3644022, a potent freely reversible ATP-competitive compound that inhibits MK2 activity (Ki = 3 nM) with good selectivity when profiled against 200 human kinases. PF-3644022 is a benzothiophene inhibitor of mitogen-activated protein kinase-activated protein kinase 2 inhibits tumor necrosis factor α production and has oral anti-inflammatory efficacy in acute and chronic models of inflammation. |
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