cabozantinib
Cabozantinib is used in two forms. A capsule form is used since 2012 to treat medullary thyroid cancer and a tablet form is used since 2016 as a second line treatment for renal cell carcinoma.. Reference standards of Cabozantinib API, and its pharmacopeial, non pharmacopeial impurities, and stable isotopes are listed below
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[weight] => 501.51
[form] => C28H24FN3O5
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Cabozantinib - API Standards
Catalogue No.:PA 30 62000
Molecular Formula : C28H24FN3O5
Molecular Weight : 501.51
stdClass Object
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[pname] => Cabozantinib Amine Analog
[catalogue_number] => PA 30 62550
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[chemical_name] =>
[weight] => 296.32
[form] => C17H16N2O3
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Cabozantinib Amine Analog
Catalogue No.:PA 30 62550
Molecular Formula : C17H16N2O3
Molecular Weight : 296.32
stdClass Object
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[pname] => Cabozantinib L-Malate Salt
[catalogue_number] => PA 30 62590
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[chemical_name] =>
[weight] => 635.59
[form] => C32H30FN3O10
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Cabozantinib L-Malate Salt
Catalogue No.:PA 30 62590
Molecular Formula : C32H30FN3O10
Molecular Weight : 635.59
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[pname] => Cabozantinib Chloro Analog
[catalogue_number] => PA 30 62530
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[weight] => 223.66
[form] => C11H10ClNO2
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Cabozantinib Chloro Analog
Catalogue No.:PA 30 62530
Molecular Formula : C11H10ClNO2
Molecular Weight : 223.66
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[pname] => Cabozantinib Nitro Analog
[catalogue_number] => PA 30 62540
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[weight] => 326.3
[form] => C17H14N2O5
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Cabozantinib Nitro Analog
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[form] => C22H20N2O6
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Cabozantinib Carboxylic Acid Analog
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[pname] => Cabozantinib Methyl Ester Analog
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Cabozantinib Methyl Ester Analog
Catalogue No.:PA 30 62570
Molecular Formula : C23H22N2O6
Molecular Weight : 422.43
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[pname] => Cabozantinib Ethyl Ester Analog
[catalogue_number] => PA 30 62580
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[weight] => 436.46
[form] => C24H24N2O6
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Cabozantinib Ethyl Ester Analog
Catalogue No.:PA 30 62580
Molecular Formula : C24H24N2O6
Molecular Weight : 436.46
stdClass Object
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[pname] => N-(4-Fluorophenyl)-n'-(4-hydroxyphenyl)cyclopropane-1,1-dicarboxamide
[catalogue_number] => PA 30 62610
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[weight] => 314.31
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N-(4-Fluorophenyl)-n'-(4-hydroxyphenyl)cyclopropane-1,1-dicarboxamide
Catalogue No.:PA 30 62610
Molecular Formula : C17H15FN2O3
Molecular Weight : 314.31
stdClass Object
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[pname] => N1,N2-Bis(4-((6,7-dimethoxyquinolin-4-yl)oxy)phenyl)oxalamide
[catalogue_number] => PA 30 62620
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N1,N2-Bis(4-((6,7-dimethoxyquinolin-4-yl)oxy)phenyl)oxalamide
Catalogue No.:PA 30 62620
Molecular Formula : C36H30N4O8
Molecular Weight : 646.65
stdClass Object
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[pname] => 4-Fluoroaniline Hydrochloride
[catalogue_number] => PA 30 0621000
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[weight] => 147.58
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4-Fluoroaniline Hydrochloride
Catalogue No.:PA 30 0621000
Molecular Formula : C6H7ClFN
Molecular Weight : 147.58
stdClass Object
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[pname] => 3,4-Dimethoxyaniline Hydrochloride
[catalogue_number] => PA 30 0621001
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[chemical_name] =>
[weight] => 189.64
[form] => C8H12ClNO2
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3,4-Dimethoxyaniline Hydrochloride
Catalogue No.:PA 30 0621001
Molecular Formula : C8H12ClNO2
Molecular Weight : 189.64
stdClass Object
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[pname] => Cabozantinib Carboxylic Acid Analog
[catalogue_number] => PA 30 0621004
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[weight] => 408.4
[form] => C22H20N2O6
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Cabozantinib Carboxylic Acid Analog
stdClass Object
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[pname] => N,N'-Bis(4-fluorophenyl)cyclopropane-1,1-dicarboxamide;
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[chemical_name] =>
[weight] => 316.31
[form] => C17H14F2N2O2
[cas] => 1431468-36-8
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N,N'-Bis(4-fluorophenyl)cyclopropane-1,1-dicarboxamide;
Catalogue No.:PA 30 0621005
Molecular Formula : C17H14F2N2O2
Molecular Weight : 316.31
stdClass Object
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[pname] => Cabozantinib Desfluoro Impurity
[catalogue_number] => PA 30 0621006
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[chemical_name] =>
[weight] => 483.52
[form] => C28H25N3O5
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Cabozantinib Desfluoro Impurity
Catalogue No.:PA 30 0621006
Molecular Formula : C28H25N3O5
Molecular Weight : 483.52
stdClass Object
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[pname] => 1-((4-((7-Methoxy-6-(sulfooxy)quinolin-4-yl)oxy)phenyl)carbamoyl)cyclopropane-1-carboxylic Acid
[catalogue_number] => PA 30 0621010
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[weight] => 474.44
[form] => C21H18N2O9S
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1-((4-((7-Methoxy-6-(sulfooxy)quinolin-4-yl)oxy)phenyl)carbamoyl)cyclopropane-1-carboxylic Acid
Catalogue No.:PA 30 0621010
Molecular Formula : C21H18N2O9S
Molecular Weight : 474.44
stdClass Object
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[pname] => N-(4-((6,7-Dimethoxyquinolin-4-yl)oxy)phenyl)-N-(4-fluoro-2-hydroxyphenyl)cyclopropane-1,1-dicarboxamide
[catalogue_number] => PA 30 0621011
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[weight] => 517.51
[form] => C28H24FN3O6
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N-(4-((6,7-Dimethoxyquinolin-4-yl)oxy)phenyl)-N-(4-fluoro-2-hydroxyphenyl)cyclopropane-1,1-dicarboxamide
Catalogue No.:PA 30 0621011
Molecular Formula : C28H24FN3O6
Molecular Weight : 517.51
stdClass Object
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[pname] => N,N'-bis(4-((6,7-dimethoxyquinolin-4-yl)oxy)phenyl)cyclopropane-1,1-dicarboxamide
[catalogue_number] => PA 30 0621013
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[chemical_name] =>
[weight] => 686.72
[form] => C39H34N4O8
[cas] => 2439164-91-5
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N,N'-bis(4-((6,7-dimethoxyquinolin-4-yl)oxy)phenyl)cyclopropane-1,1-dicarboxamide
Catalogue No.:PA 30 0621013
Molecular Formula : C39H34N4O8
Molecular Weight : 686.72
stdClass Object
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[pname] => Cabozantinib N-oxide
[catalogue_number] => PA 30 0621003
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[weight] => 517.51
[form] => C28H24FN3O6
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Catalogue No.:PA 30 0621003
Molecular Formula : C28H24FN3O6
Molecular Weight : 517.51
stdClass Object
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[pname] => 4-Chloro-6,7-dimethoxyquinoline
[catalogue_number] => PA 30 0621007
[category_ids] => ,75,76,78,70,82,
[chemical_name] =>
[weight] => 223.66
[form] => C11H10ClNO2
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4-Chloro-6,7-dimethoxyquinoline
Catalogue No.:PA 30 0621007
Molecular Formula : C11H10ClNO2
Molecular Weight : 223.66
stdClass Object
(
[pname] => Methyl 1-((4-((6,7-dimethoxyquinolin-4-yl)oxy)phenyl)carbamoyl)cyclopropane-1-carboxylate
[catalogue_number] => PA 30 0621008
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[chemical_name] =>
[weight] => 422.44
[form] => C23H22N2O6
[cas] => 1584696-82-1
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Methyl 1-((4-((6,7-dimethoxyquinolin-4-yl)oxy)phenyl)carbamoyl)cyclopropane-1-carboxylate
Catalogue No.:PA 30 0621008
Molecular Formula : C23H22N2O6
Molecular Weight : 422.44
stdClass Object
(
[pname] => Ethyl 1-((4-((6,7-dimethoxyquinolin-4-yl)oxy)phenyl)carbamoyl)cyclopropane-1-carboxylate
[catalogue_number] => PA 30 0621009
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[chemical_name] =>
[weight] => 436.46
[form] => C24H24N2O6
[cas] => 1584696-80-9
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Ethyl 1-((4-((6,7-dimethoxyquinolin-4-yl)oxy)phenyl)carbamoyl)cyclopropane-1-carboxylate
Catalogue No.:PA 30 0621009
Molecular Formula : C24H24N2O6
Molecular Weight : 436.46
stdClass Object
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[pname] => N-(4-((6,7-Dimethoxyquinolin-4-yl)oxy)phenyl)-N-(3-fluorophenyl)cyclopropane-1,1-dicarboxamide
[catalogue_number] => PA 30 0621014
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[weight] => 501.51
[form] => C28H24FN3O5
[cas] => NA
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N-(4-((6,7-Dimethoxyquinolin-4-yl)oxy)phenyl)-N-(3-fluorophenyl)cyclopropane-1,1-dicarboxamide
Catalogue No.:PA 30 0621014
Molecular Formula : C28H24FN3O5
Molecular Weight : 501.51
stdClass Object
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[weight] => 505.54
[form] => C28H20D4FN3O5
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Catalogue No.:PA STI 089396
Molecular Formula : C28H20D4FN3O5
Molecular Weight : 505.54
stdClass Object
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[catalogue_number] => PA 30 0621015
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[weight] => 326.31
[form] => C17H14N2O5
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6,7-Dimethoxy-4-(2-nitrophenoxy)quinoline
Catalogue No.:PA 30 0621015
Molecular Formula : C17H14N2O5
Molecular Weight : 326.31
stdClass Object
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[catalogue_number] => PA 30 0621016
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[weight] => 296.33
[form] => C17H16N2O3
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3-((6,7-Dimethoxyquinolin-4-yl)oxy)aniline
Catalogue No.:PA 30 0621016
Molecular Formula : C17H16N2O3
Molecular Weight : 296.33
stdClass Object
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6,7-Dimethoxy-4-(3-nitrophenoxy)quinoline
Catalogue No.:PA 30 0621017
Molecular Formula : C17H14N2O5
Molecular Weight : 326.31
stdClass Object
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[weight] => 205.21
[form] => C11H11NO3
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1-(Phenylcarbamoyl)cyclopropane-1-carboxylic Acid
Catalogue No.:PA 30 0621018
Molecular Formula : C11H11NO3
Molecular Weight : 205.21
stdClass Object
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[weight] => 223.2
[form] => C11H10FNO3
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1-((3-Fluorophenyl)carbamoyl)cyclopropane-1-carboxylic Acid
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[weight] => 223.2
[form] => C11H10FNO3
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1-((2-Fluorophenyl)carbamoyl)cyclopropane-1-carboxylic Acid
stdClass Object
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[catalogue_number] => PA 30 0621021
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[weight] => 296.33
[form] => C17H16N2O3
[cas] => 190728-27-9
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2-((6,7-Dimethoxyquinolin-4-yl)oxy)aniline
Catalogue No.:PA 30 0621021
Molecular Formula : C17H16N2O3
Molecular Weight : 296.33
stdClass Object
(
[pname] => N-(4-((6,7-Dimethoxyquinolin-4-yl)oxy)phenyl)-6,7-dimethoxyquinolin-4-amine
[catalogue_number] => PA 30 0621022
[category_ids] => ,75,76,79,80,71,78,82,
[chemical_name] =>
[weight] => 483.52
[form] => C28H25N3O5
[cas] => NA
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N-(4-((6,7-Dimethoxyquinolin-4-yl)oxy)phenyl)-6,7-dimethoxyquinolin-4-amine
Catalogue No.:PA 30 0621022
Molecular Formula : C28H25N3O5
Molecular Weight : 483.52
stdClass Object
(
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[catalogue_number] => PA 30 0621023
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[chemical_name] =>
[weight] => 153.18
[form] => C8H11NO2
[cas] => 6315-89-5
[pslug] => 6315-89-5-3-4-dimethoxyaniline-pa300621023
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Catalogue No.:PA 30 0621023
Molecular Formula : C8H11NO2
Molecular Weight : 153.18
stdClass Object
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[weight] => 487.49
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N-(4-Fluorophenyl)-N-(4-((7-hydroxy-6-methoxyquinolin-4-yl)oxy)phenyl)cyclopropane-1,1-dicarboxamide
Catalogue No.:PA 30 0621024
Molecular Formula : C27H22FN3O5
Molecular Weight : 487.49
stdClass Object
(
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[weight] => 487.49
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N-(4-Fluorophenyl)-N-(4-((6-hydroxy-7-methoxyquinolin-4-yl)oxy)phenyl)cyclopropane-1,1-dicarboxamide
Catalogue No.:PA 30 0621025
Molecular Formula : C27H22FN3O5
Molecular Weight : 487.49
stdClass Object
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[catalogue_number] => PA 30 0621026
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[weight] => 282.3
[form] => C16H14N2O3
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4-(4-Aminophenoxy)-6-methoxyquinolin-7-ol
stdClass Object
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[weight] => 282.3
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4-(4-Aminophenoxy)-7-methoxyquinolin-6-ol
stdClass Object
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[catalogue_number] => PA 30 0621028
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[chemical_name] =>
[weight] => 241.19
[form] => C11H9F2NO3
[cas] => 1275738-77-6
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1-((3,4-Difluorophenyl)carbamoyl)cyclopropane-1-carboxylic Acid
Catalogue No.:PA 30 0621028
Molecular Formula : C11H9F2NO3
Molecular Weight : 241.19
stdClass Object
(
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[catalogue_number] => PA 30 0621029
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[weight] => 237.23
[form] => C12H12FNO3
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Methyl 1-((4-fluorophenyl)carbamoyl)cyclopropane-1-carboxylate
Catalogue No.:PA 30 0621029
Molecular Formula : C12H12FNO3
Molecular Weight : 237.23
stdClass Object
(
[pname] => (2S,3S,4S,5R,6S)-6-((4-(4-(1-((4-Fluorophenyl)carbamoyl)cyclopropane-1-carboxamido)phenoxy)-6-methoxyquinolin-7-yl)oxy)-3,4,5-trihydroxytetrahydro-2H-pyran-2-carboxylic Acid
[catalogue_number] => PA 30 0621030
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[weight] => 663.61
[form] => C33H30FN3O11
[cas] => NA
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(2S,3S,4S,5R,6S)-6-((4-(4-(1-((4-Fluorophenyl)carbamoyl)cyclopropane-1-carboxamido)phenoxy)-6-methoxyquinolin-7-yl)oxy)-3,4,5-trihydroxytetrahydro-2H-pyran-2-carboxylic Acid
Catalogue No.:PA 30 0621030
Molecular Formula : C33H30FN3O11
Molecular Weight : 663.61
stdClass Object
(
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[catalogue_number] => PA 30 0621031
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[weight] => 296.33
[form] => C17H16N2O3
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4-((6,7-Dimethoxyquinolin-4-yl)amino)phenol
Catalogue No.:PA 30 0621031
Molecular Formula : C17H16N2O3
Molecular Weight : 296.33
stdClass Object
(
[pname] => (E)-N-(3-(4,5-Dimethoxy-2-nitrophenyl)-3-oxoprop-1-en-1-yl)-N-methylnitrous amide
[catalogue_number] => PA 30 0621032
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[chemical_name] =>
[weight] => 295.25
[form] => C12H13N3O6
[cas] => NA
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(E)-N-(3-(4,5-Dimethoxy-2-nitrophenyl)-3-oxoprop-1-en-1-yl)-N-methylnitrous amide
Catalogue No.:PA 30 0621032
Molecular Formula : C12H13N3O6
Molecular Weight : 295.25
stdClass Object
(
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[catalogue_number] => PA 30 0621033
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[weight] => 1003.03
[form] => C56H48F2N6O10
[cas] => NA
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4-((4-((6,7-Dimethoxyquinolin-4-yl)oxy)phenyl)amino)-3-((4-fluorophenyl)carbamoyl)-4-oxobutyl (Z)-N-(4-((6,7-dimethoxyquinolin-4-yl)oxy)phenyl)-1-((4-fluorophenyl)carbamoyl)cyclopropane-1-carbimidate
Catalogue No.:PA 30 0621033
Molecular Formula : C56H48F2N6O10
Molecular Weight : 1003.03
stdClass Object
(
[pname] => 5-(((3,4-Dimethoxyphenyl)amino)methylene)-2,2-dimethyl-1,3-dioxane-4,6-dione
[catalogue_number] => PA 30 0621034
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[chemical_name] =>
[weight] => 307.3
[form] => C15H17NO6
[cas] => 213699-53-7
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5-(((3,4-Dimethoxyphenyl)amino)methylene)-2,2-dimethyl-1,3-dioxane-4,6-dione