Larotrectinib

Fine Chemicals - Larotrectinib (tradename Vitrakvi) is a drug for the treatment of cancer.It is an inhibitor of tropomyosin kinase receptors TrkA, TrkB, and TrkC. It was discovered by Array BioPharma and licensed to Loxo Oncology in 2013. Reference standards of Larotrectinib API,and its pharmacopeial, non pharmacopeial impurities, and stable isotopes are listed below.

stdClass Object
(
    [pname] => Larotrectinib
    [catalogue_number] => PA 12 1480000
    [category_ids] => ,78,75,70,76,82,
    [chemical_name] => 
    [weight] => 428.44
    [form] => C21H22F2N6O2
    [cas] => 1223403-58-4
    [pslug] => 1223403-58-4-larotrectinib-api-pa121480000
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PA 12 1480000
PA 12 1480000

Larotrectinib

  • Catalogue No.:PA 12 1480000

  • CAS :

    1223403-58-4

  • Molecular Formula : C21H22F2N6O2

  • Molecular Weight : 428.44

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stdClass Object
(
    [pname] => (S)-N-(5-Chloropyrazolo[1,5-a]pyrimidin-3-yl)-3-hydroxypyrrolidine-1-carboxamide
    [catalogue_number] => PA 12 1481000
    [category_ids] => ,75,76,78,70,82,
    [chemical_name] => 
    [weight] => 281.7
    [form] => C11H12ClN5O2
    [cas] => 2226370-52-9
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PA 12 1481000
PA 12 1481000

(S)-N-(5-Chloropyrazolo[1,5-a]pyrimidin-3-yl)-3-hydroxypyrrolidine-1-carboxamide

  • Catalogue No.:PA 12 1481000

  • CAS :

    2226370-52-9

  • Molecular Formula : C11H12ClN5O2

  • Molecular Weight : 281.7

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Details 
stdClass Object
(
    [pname] => (S)-1-benzyl-3-hydroxypyrrolidine-2,5-dione
    [catalogue_number] => PA 12 1481002
    [category_ids] => ,75,76,78,70,82,
    [chemical_name] => 
    [weight] => 205.21
    [form] => C11H11NO3
    [cas] => 101469-91-4
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PA 12 1481002
PA 12 1481002

(S)-1-benzyl-3-hydroxypyrrolidine-2,5-dione

  • Catalogue No.:PA 12 1481002

  • CAS :

    101469-91-4

  • Molecular Formula : C11H11NO3

  • Molecular Weight : 205.21

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Details 
stdClass Object
(
    [pname] => (S)-1-benzylpyrrolidin-3-ol
    [catalogue_number] => PA 12 1481001
    [category_ids] => ,75,76,78,70,82,
    [chemical_name] => 
    [weight] => 177.25
    [form] => C11H15NO
    [cas] => 101385-90-4
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PA 12 1481001
PA 12 1481001

(S)-1-benzylpyrrolidin-3-ol

  • Catalogue No.:PA 12 1481001

  • CAS :

    101385-90-4

  • Molecular Formula : C11H15NO

  • Molecular Weight : 177.25

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stdClass Object
(
    [pname] => Larotrectinib Open-Ring Dimer
    [catalogue_number] => PA 12 1481003
    [category_ids] => ,78,75,70,76,82,
    [chemical_name] => 
    [weight] => 515.57
    [form] => C25H31F2N7O3
    [cas] => NA
    [pslug] => larotrectinib-open-ring-dimer-pa121481003
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PA 12 1481003
PA 12 1481003

Larotrectinib Open-Ring Dimer

  • Catalogue No.:PA 12 1481003

  • CAS :

    NA

  • Molecular Formula : C25H31F2N7O3

  • Molecular Weight : 515.57

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stdClass Object
(
    [pname] => 1-(4-Bromo-3-fluorophenyl)ethan-1-one
    [catalogue_number] => PA 12 1481004
    [category_ids] => ,78,75,70,76,82,
    [chemical_name] => 
    [weight] => 217.04
    [form] => C8H6BrFO
    [cas] => 304445-49-6
    [pslug] => 304445-49-6-1-4-bromo-3-fluorophenyl-ethan-1-one-pa121481004
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PA 12 1481004
PA 12 1481004

1-(4-Bromo-3-fluorophenyl)ethan-1-one

  • Catalogue No.:PA 12 1481004

  • CAS :

    304445-49-6

  • Molecular Formula : C8H6BrFO

  • Molecular Weight : 217.04

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Details 
stdClass Object
(
    [pname] => 4-Acetyl-2-fluorobenzonitrile
    [catalogue_number] => PA 12 1481005
    [category_ids] => ,78,75,70,76,82,
    [chemical_name] => 
    [weight] => 163.15
    [form] => C9H6FNO
    [cas] => 214760-18-6
    [pslug] => 214760-18-6-4-acetyl-2-fluorobenzonitrile-pa121481005
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PA 12 1481005
PA 12 1481005

4-Acetyl-2-fluorobenzonitrile

  • Catalogue No.:PA 12 1481005

  • CAS :

    214760-18-6

  • Molecular Formula : C9H6FNO

  • Molecular Weight : 163.15

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Details 
stdClass Object
(
    [pname] => (R)-5-(2-(2,5-Difluorophenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyrimidin-3-amine
    [catalogue_number] => PA 12 1481006
    [category_ids] => ,78,75,70,76,82,
    [chemical_name] => 
    [weight] => 315.33
    [form] => C16H15F2N5
    [cas] => 1223404-88-3
    [pslug] => 1223404-88-3-r-5-2-2-5-difluorophenyl-pyrrolidin-1-yl-pyrazolo-1-5-a-pyrimidin-3-amine-pa121481006
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PA 12 1481006
PA 12 1481006

(R)-5-(2-(2,5-Difluorophenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyrimidin-3-amine

  • Catalogue No.:PA 12 1481006

  • CAS :

    1223404-88-3

  • Molecular Formula : C16H15F2N5

  • Molecular Weight : 315.33

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stdClass Object
(
    [pname] => 1,3-Bis(5-((R)-2-(2,5-difluorophenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyrimidin-3-yl)urea
    [catalogue_number] => PA 12 1481007
    [category_ids] => ,78,75,70,76,82,
    [chemical_name] => 
    [weight] => 656.65
    [form] => C33H28F4N10O
    [cas] => NA
    [pslug] => 1-3-bis-5-r-2-2-5-difluorophenyl-pyrrolidin-1-yl-pyrazolo-1-5-a-pyrimidin-3-yl-urea-pa121481007
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PA 12 1481007
PA 12 1481007

1,3-Bis(5-((R)-2-(2,5-difluorophenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyrimidin-3-yl)urea

  • Catalogue No.:PA 12 1481007

  • CAS :

    NA

  • Molecular Formula : C33H28F4N10O

  • Molecular Weight : 656.65

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Details 
stdClass Object
(
    [pname] => (R)-N-(5-(2-(2,5-Difluorophenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyrimidin-3-yl)-2,3-dihydro-1H-pyrrole-1-carboxamide
    [catalogue_number] => PA 12 1481008
    [category_ids] => ,78,75,70,76,82,
    [chemical_name] => 
    [weight] => 410.43
    [form] => C21H20F2N6O
    [cas] => NA
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PA 12 1481008
PA 12 1481008

(R)-N-(5-(2-(2,5-Difluorophenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyrimidin-3-yl)-2,3-dihydro-1H-pyrrole-1-carboxamide

  • Catalogue No.:PA 12 1481008

  • CAS :

    NA

  • Molecular Formula : C21H20F2N6O

  • Molecular Weight : 410.43

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stdClass Object
(
    [pname] => (R)-N-(5-(2-(2,5-Difluorophenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyrimidin-3-yl)-2,3-dihydro-1H-pyrrole-1-carboxamide
    [catalogue_number] => PA 12 1481009
    [category_ids] => ,78,75,70,76,82,
    [chemical_name] => 
    [weight] => 426.43
    [form] => C21H20F2N6O2
    [cas] => 2699151-02-3
    [pslug] => 2699151-02-3-r-n-5-2-2-5-difluorophenyl-pyrrolidin-1-yl-pyrazolo-1-5-a-pyrimidin-3-yl-2-3-dihydro-1h-pyrrole-1-carboxamide-pa121481009
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PA 12 1481009
PA 12 1481009

(R)-N-(5-(2-(2,5-Difluorophenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyrimidin-3-yl)-2,3-dihydro-1H-pyrrole-1-carboxamide

  • Catalogue No.:PA 12 1481009

  • CAS :

    2699151-02-3

  • Molecular Formula : C21H20F2N6O2

  • Molecular Weight : 426.43

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Details 
stdClass Object
(
    [pname] => (2R)-2-(2,5-Difluorophenyl)-1-(3-((S)-3-hydroxypyrrolidine-1-carboxamido)pyrazolo[1,5-a]pyrimidin-5-yl)pyrrolidine 1-oxide
    [catalogue_number] => PA 12 1481010
    [category_ids] => ,78,75,70,76,82,
    [chemical_name] => 
    [weight] => 444.44
    [form] => C21H22F2N6O3
    [cas] => NA
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PA 12 1481010
PA 12 1481010

(2R)-2-(2,5-Difluorophenyl)-1-(3-((S)-3-hydroxypyrrolidine-1-carboxamido)pyrazolo[1,5-a]pyrimidin-5-yl)pyrrolidine 1-oxide

  • Catalogue No.:PA 12 1481010

  • CAS :

    NA

  • Molecular Formula : C21H22F2N6O3

  • Molecular Weight : 444.44

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Details 
stdClass Object
(
    [pname] => (R)-2-(2,5-Difluorophenyl)-1-nitrosopyrrolidine
    [catalogue_number] => PA 12 1481011
    [category_ids] => ,78,75,70,76,82,162,
    [chemical_name] => 
    [weight] => 212.2
    [form] => C10H10F2N2O
    [cas] => NA
    [pslug] => r-2-2-5-difluorophenyl-1-nitrosopyrrolidine-pa121481011
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PA 12 1481011
PA 12 1481011

(R)-2-(2,5-Difluorophenyl)-1-nitrosopyrrolidine

  • Catalogue No.:PA 12 1481011

  • CAS :

    NA

  • Molecular Formula : C10H10F2N2O

  • Molecular Weight : 212.2

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Details 
stdClass Object
(
    [pname] => (S)-N-(5-((R)-2-(2,5-Difluorophenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyrimidin-3-yl)-3-hydroxy-N-nitrosopyrrolidine-1-carboxamide
    [catalogue_number] => PA 12 1481012
    [category_ids] => ,78,75,70,76,82,162,
    [chemical_name] => 
    [weight] => 457.44
    [form] => C21H21F2N7O3
    [cas] => NA
    [pslug] => s-n-5-r-2-2-5-difluorophenyl-pyrrolidin-1-yl-pyrazolo-1-5-a-pyrimidin-3-yl-3-hydroxy-n-nitrosopyrrolidine-1-carboxamide-pa121481012
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PA 12 1481012
PA 12 1481012

(S)-N-(5-((R)-2-(2,5-Difluorophenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyrimidin-3-yl)-3-hydroxy-N-nitrosopyrrolidine-1-carboxamide

  • Catalogue No.:PA 12 1481012

  • CAS :

    NA

  • Molecular Formula : C21H21F2N7O3

  • Molecular Weight : 457.44

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