sorafenib
A tosylate salt of Sorafenib which is a kinase inhibitor drug. It is used for the treatment of kidney, liver and thyroid cancer. It works by inhibiting the VEGFR-2/PDGFR-beta signaling cascade, thereby blocking tumor angiogenesis. Reference standards of Sorafenib API,and its pharmacopeial, non pharmacopeial impurities, and stable isotopes are listed below.
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[pname] => Sorafenib - API Standards
[catalogue_number] => PA 46 17000
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[weight] => 464.82
[form] => C21H16ClF3N4O3
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Sorafenib - API Standards
Catalogue No.:PA 46 17000
Molecular Formula : C21H16ClF3N4O3
Molecular Weight : 464.82
stdClass Object
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[pname] => Flucofuron
[catalogue_number] => PA 46 17610
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[weight] => 417.13
[form] => C15H8Cl2F6N2O
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Catalogue No.:PA 46 17610
Molecular Formula : C15H8Cl2F6N2O
Molecular Weight : 417.13
stdClass Object
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[pname] => Sorafenib β-D-Glucuronide
[catalogue_number] => PA 19 69540
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[chemical_name] =>
[weight] => 640.95
[form] => C27H24ClF3N4O9
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Sorafenib β-D-Glucuronide
Catalogue No.:PA 19 69540
Molecular Formula : C27H24ClF3N4O9
Molecular Weight : 640.95
stdClass Object
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[pname] => Sorafenib Hemi-Tosylate
[catalogue_number] => PA 19 69550
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[chemical_name] =>
[weight] => 464.83
[form] => C21H16ClF3N4O3 .1/2 C7H8O3S
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Catalogue No.:PA 19 69550
Molecular Formula : C21H16ClF3N4O3 .1/2 C7H8O3S
Molecular Weight : 464.83
stdClass Object
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[pname] => Sorafenib-d3
[catalogue_number] => PA STI 079660
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[chemical_name] =>
[weight] => 467.84
[form] => C21H13D3ClF3N4O3
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Catalogue No.:PA STI 079660
Molecular Formula : C21H13D3ClF3N4O3
Molecular Weight : 467.84
stdClass Object
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[pname] => N-Desmethyl Sorafenib
[catalogue_number] => PA 46 17630
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stdClass Object
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[pname] => 1,3-bis(6-Chloro-2',3'-difluoro-[1,1'-biphenyl]-3-yl)urea
[catalogue_number] => PA 46 17640
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[weight] => 505.29
[form] => C25H14Cl2F4N2O
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1,3-bis(6-Chloro-2',3'-difluoro-[1,1'-biphenyl]-3-yl)urea
Catalogue No.:PA 46 17640
Molecular Formula : C25H14Cl2F4N2O
Molecular Weight : 505.29
stdClass Object
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[weight] => 513.51
[form] => C27H23N5O6
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Des-(4-chloro-3-trifluoromethyl)-4-(methyl-4-hydroxypicolinate) Sorafenib
Catalogue No.:PA 46 17660
Molecular Formula : C27H23N5O6
Molecular Weight : 513.51
stdClass Object
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4-(Trifluoromethoxy)phenyl Isothiocyanate
Catalogue No.:PA 46 17650
Molecular Formula : C8H4F3NOS
Molecular Weight : 219.18
stdClass Object
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[pname] => 4-(4-Aminophenoxy)-N-ethylpicolinamide
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4-(4-Aminophenoxy)-N-ethylpicolinamide
Catalogue No.:PA 46 17670
Molecular Formula : C14H15N3O2
Molecular Weight : 257.29
stdClass Object
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[pname] => 4-(Hydroxyamino)phenol
[catalogue_number] => PA 46 0171000
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[chemical_name] =>
[weight] => 125.13
[form] => C6H7NO2
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Catalogue No.:PA 46 0171000
Molecular Formula : C6H7NO2
Molecular Weight : 125.13
stdClass Object
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[pname] => Sorafenib Hydroxydemethylamine
[catalogue_number] => PA 46 0171001
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[weight] => 451.79
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Sorafenib Hydroxydemethylamine
Catalogue No.:PA 46 0171001
Molecular Formula : C20H13ClF3N3O4
Molecular Weight : 451.79
stdClass Object
(
[pname] => 4-(4-Aminophenoxy)picolinic acid
[catalogue_number] => PA 46 0171002
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[chemical_name] =>
[weight] => 230.22
[form] => C12H10N2O3
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4-(4-Aminophenoxy)picolinic acid
Catalogue No.:PA 46 0171002
Molecular Formula : C12H10N2O3
Molecular Weight : 230.22
stdClass Object
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[pname] => 4-(3-(3-(4-Chloro-3-(trifluoromethyl)phenyl)ureido)phenoxy)-N-methylpicolinamide
[catalogue_number] => PA 19 0691000
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[weight] => 464.83
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4-(3-(3-(4-Chloro-3-(trifluoromethyl)phenyl)ureido)phenoxy)-N-methylpicolinamide
Catalogue No.:PA 19 0691000
Molecular Formula : C21H16ClF3N4O3
Molecular Weight : 464.83
stdClass Object
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N-Desmethyl Sorafenib (Pyridine)-N-oxide
stdClass Object
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[weight] => 330.69
[form] => C14H10ClF3N2O2
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1-(4-Chloro-3-trifluoromethylphenyl)-3-(4-hydroxyphenyl)urea
Catalogue No.:PA 19 0691002
Molecular Formula : C14H10ClF3N2O2
Molecular Weight : 330.69
stdClass Object
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[pname] => 2-Chloro-1-isocyanato-3-(trifluoromethyl)benzene
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[weight] => 221.56
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2-Chloro-1-isocyanato-3-(trifluoromethyl)benzene
Catalogue No.:PA 46 0171003
Molecular Formula : C8H3ClF3NO
Molecular Weight : 221.56
stdClass Object
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N-Methyl-4-phenoxypicolinamide
Catalogue No.:PA 46 0171004
Molecular Formula : C13H12N2O2
Molecular Weight : 228.25
stdClass Object
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Phenyl (4-chloro-3-(trifluoromethyl)phenyl)carbamate
Catalogue No.:PA 46 0171005
Molecular Formula : C14H9ClF3NO2
Molecular Weight : 315.68
stdClass Object
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[weight] => 238.59
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1-(4-Chloro-3-(trifluoromethyl)phenyl)urea
Catalogue No.:PA 46 0171006
Molecular Formula : C8H6ClF3N2O
Molecular Weight : 238.59
stdClass Object
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[weight] => 170.6
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6-Chloro-N-methyl-2-pyridinecarboxamide
stdClass Object
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[pname] => N-Methylpicolinamide hydrochloride
[catalogue_number] => PA 46 0171008
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[chemical_name] =>
[weight] => 172.61
[form] => C7H9ClN2O
[cas] => NA
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N-Methylpicolinamide hydrochloride
Catalogue No.:PA 46 0171008
Molecular Formula : C7H9ClN2O
Molecular Weight : 172.61
stdClass Object
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[catalogue_number] => PAI 19 069001
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[weight] => 315.68
[form] => C14H9ClF3NO2
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Phenyl (2-chloro-3-(trifluoromethyl)phenyl)carbamate
Catalogue No.:PAI 19 069001
Molecular Formula : C14H9ClF3NO2
Molecular Weight : 315.68
stdClass Object
(
[pname] => N-(2-Chloro-3-(trifluoromethyl)phenyl)-O-pivaloylhydroxylamine
[catalogue_number] => PAI 19 069002
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[chemical_name] =>
[weight] => 295.69
[form] => C12H13ClF3NO2
[cas] => NA
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N-(2-Chloro-3-(trifluoromethyl)phenyl)-O-pivaloylhydroxylamine
Catalogue No.:PAI 19 069002
Molecular Formula : C12H13ClF3NO2
Molecular Weight : 295.69
stdClass Object
(
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[catalogue_number] => PA 46 0171010
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[chemical_name] =>
[weight] => 478.86
[form] => C22H18ClF3N4O3
[cas] => 284461-82-1
[pslug] => 284461-82-1-4-4-3-4-chloro-3-trifluoromethyl-phenyl-ureido-phenox-yl-n-ethylpicolinamide-pa460171010
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4-(4-(3-(4-Chloro-3(trifluoromethyl)phenyl)ureido)phenox yl)-n-ethylpicolinamide
Catalogue No.:PA 46 0171010
Molecular Formula : C22H18ClF3N4O3
Molecular Weight : 478.86
stdClass Object
(
[pname] => N-Methyl-4-(4-ureidophenoxy)picolinamide
[catalogue_number] => PA 46 0171009
[category_ids] => ,75,76,78,70,82,
[chemical_name] =>
[weight] => 286.29
[form] => C14H14N4O3
[cas] => 1129683-88-0
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N-Methyl-4-(4-ureidophenoxy)picolinamide
Catalogue No.:PA 46 0171009
Molecular Formula : C14H14N4O3
Molecular Weight : 286.29
stdClass Object
(
[pname] => 4-Chloro-N-methyl-N-(2-(methylcarbamoyl)pyridin-4-yl)picolinamide
[catalogue_number] => PA 46 0171011
[category_ids] => ,78,70,82,
[chemical_name] =>
[weight] => 304.73
[form] => C14H13ClN4O2
[cas] => NA
[pslug] => 4-chloro-n-methyl-n-2-methylcarbamoyl-pyridin-4-yl-picolinamide-pa460171011
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4-Chloro-N-methyl-N-(2-(methylcarbamoyl)pyridin-4-yl)picolinamide
Catalogue No.:PA 46 0171011
Molecular Formula : C14H13ClN4O2
Molecular Weight : 304.73
stdClass Object
(
[pname] => Methyl 4-(4-aminophenoxy)picolinate
[catalogue_number] => PA 46 0171012
[category_ids] => ,79,81,78,70,82,
[chemical_name] =>
[weight] => 244.25
[form] => C13H12N2O3
[cas] => 757251-59-5
[pslug] => 757251-59-5-methyl-4-4-aminophenoxy-picolinate-pa460171012
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Methyl 4-(4-aminophenoxy)picolinate
Catalogue No.:PA 46 0171012
Molecular Formula : C13H12N2O3
Molecular Weight : 244.25
stdClass Object
(
[pname] => Sorafenib Carboxylic Acid Methyl Ester
[catalogue_number] => PA 46 0171013
[category_ids] => ,79,81,78,70,82,
[chemical_name] =>
[weight] => 465.81
[form] => C21H15ClF3N3O4
[cas] => 573673-43-5
[pslug] => 573673-43-5-sorafenib-carboxylic-acid-methyl-ester-pa460171013
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Sorafenib Carboxylic Acid Methyl Ester
Catalogue No.:PA 46 0171013
Molecular Formula : C21H15ClF3N3O4
Molecular Weight : 465.81
stdClass Object
(
[pname] => 4,4'-((((Azanediylbis(carbonyl))bis(azanediyl))bis(4,1-phenylene))bis(oxy))bis(N-methylpicolinamide)
[catalogue_number] => PA 46 0171014
[category_ids] => ,78,70,82,
[chemical_name] =>
[weight] => 555.55
[form] => C28H25N7O6
[cas] => 2206827-18-9
[pslug] => 2206827-18-9-4-4-azanediylbis-carbonyl-bis-azanediyl-bis-4-1-phenylene-bis-oxy-bis-n-methylpicolinamide-pa460171014
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4,4'-((((Azanediylbis(carbonyl))bis(azanediyl))bis(4,1-phenylene))bis(oxy))bis(N-methylpicolinamide)
Catalogue No.:PA 46 0171014
Molecular Formula : C28H25N7O6
Molecular Weight : 555.55
stdClass Object
(
[pname] => 1-(4-Ethoxy-3-(trifluoromethyl)phenyl)-3-(2-(3-(hydroxymethyl)piperidin-1-yl)ethyl)urea
[catalogue_number] => PA 46 0171015
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[chemical_name] =>
[weight] => 389.42
[form] => C18H26F3N3O3
[cas] => 1567296-47-2
[pslug] => 1567296-47-2-1-4-ethoxy-3-trifluoromethyl-phenyl-3-2-3-hydroxymethyl-piperidin-1-yl-ethyl-urea-pa460171015
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1-(4-Ethoxy-3-(trifluoromethyl)phenyl)-3-(2-(3-(hydroxymethyl)piperidin-1-yl)ethyl)urea
Catalogue No.:PA 46 0171015
Molecular Formula : C18H26F3N3O3
Molecular Weight : 389.42
stdClass Object
(
[pname] => N-Methyl-4-(methylamino)picolinamide
[catalogue_number] => PA 46 0171016
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[chemical_name] =>
[weight] => 165.2
[form] => C8H11N3O
[cas] => 1065074-98-7
[pslug] => 1065074-98-7-n-methyl-4-methylamino-picolinamide-pa460171016
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N-Methyl-4-(methylamino)picolinamide
stdClass Object
(
[pname] => 4,6-Dichloro-N-methylpicolinamide
[catalogue_number] => PA 46 0171017
[category_ids] => ,79,81,78,70,82,
[chemical_name] =>
[weight] => 205.04
[form] => C7H6Cl2N2O
[cas] => 1379324-09-0
[pslug] => 1379324-09-0-4-6-dichloro-n-methylpicolinamide-pa460171017
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4,6-Dichloro-N-methylpicolinamide
Catalogue No.:PA 46 0171017
Molecular Formula : C7H6Cl2N2O
Molecular Weight : 205.04