| Catalogue number: | PA STI 078280 |
| Chemical name: | Ro 106-9920-d5 |
CAS Number: |
NA |
| Category: | miscellaneous compounds,stable isotopes |
| Synonyms: | 6-[(Phenyl-d5)sulfinyl]tetrazolo[1,5-b]pyridazine; |
| Molecular form: | C10H2D5N5OS |
| Appearance: | NA |
| Mol. Weight: | 250.29 |
| Storage: | 2-8°C Refrigerator |
| Shipping Conditions: | Ambient |
| Applications: | Labelled Ro 106-9920 (R637500). Ro 106-9920 is an inhibitor of NF-κB activation, possibly via selective inhibition of LPS- and TNF-α-induced IκBα ubiquitination (IC50 = 3 μM). Ro 106-9920 blocks subsequent production of TNF-α, IL-1β and IL-6. Inhibits mucin production in an in vitro model of COPD, and is anti-inflammatory following oral administration in vivo. Also weakly inhibits EGFR, 5-lipoxygenase and iNOS. |
Ro 106-9920-d5
Ro 106-9920-d5
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