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Catalogue number: PA STI 008270
Chemical name: Aprepitant-d4

CAS Number:


Category: chiral standards,heterocycles,pharmaceutical standards,intermediates,fine chemicals,stable isotopes

5-[[(2R,3S)-2-[(1R)-1-[3,5-Bis(trifluoromethyl)phenyl]ethoxy]-3-(4-fluorophenyl-d4)-4-morpholinyl]methyl]-1,2-dihydro-3H-1,2,4-triazol-3-one; Emend-d4; L 754030-d4; MK 0869-d4; MK 869-d4; ONO 7436-d4;

Molecular form: C23H17D4F7N4O3
Appearance: White Solid
Mol. Weight: 538.45
Storage: 2-8°C Refrigerator
Shipping Conditions: Ambient
Applications: Aprepitant-d4 is a labeled analogue of Aprepitant, A novel selective neurokinin-1 (NK-1) receptor antagonist. In vitro studies using human liver microsomes indicate that Aprepitant is metabolised primarily by CYP3A4 with minor metabolism by CYP1A2 and CYP2C19, and no metabolism by CYP2D6, CYP2C9, or CYP2E1. Aprepitant-d4 is a potential treatment for chemotherapy induced nausea and vomiting.

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