| Catalogue number: | PA 28 0071005 |
| Chemical name: | Des-1,2,4-triazol-3-one-5-methyl (2S,3R,1'R)-aprepitant |
CAS Number: |
1185503-48-3 |
| Category: | impurities,metabolites,pharmaceutical standards,intermediates,fine chemicals |
| Synonyms: | (2S,3R)-2-((R)-1-(3,5-Bis(trifluoromethyl)phenyl)ethoxy)-3-(4-fluorophenyl)morpholine;aprepitant M2 Metabolite (1R, 2S, 3R)-Isomer; |
| Molecular form: | C20H18F7NO2 |
| Appearance: | NA |
| Mol. Weight: | 437.36 |
| Storage: | 2-8°C Refrigerator |
| Shipping Conditions: | Ambient |
| Applications: | Des-1,2,4-triazol-3-one-5-methyl (2S,3R,1'R)-Aprepitant is an impurity of Aprepitant ; a novel selective neurokinin-1 (NK-1) receptor antagonist. In vitro studies using human liver microsomes indicate that Aprepitant is metabolised primarily by CYP3A4 with minor metabolism by CYP1A2 and CYP2C19, and no metabolism by CYP2D6, CYP2C9, or CYP2E1. Antiemetic. |
| BTM: | NA |
Des-1,2,4-triazol-3-one-5-methyl (2S,3R,1'R)-aprepitant
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