Abacavir Sulfate - Impurity A (Freebase)

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Catalogue number: PA 01 01010
Chemical name: [(1R,4S)-4-[2-Amino-6-(cyclopropylamino)-9H-purin-9- yl]cyclopent-2-en-1-yl]methanol

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Category: intermediates,antiviral agents,pharmaceutical standards,enzyme inhibitors,Fine Chemicals,bases and related reagents,nucleotides

ent-Abacavir; [(1R,4S)-4-[2-Amino-6-(cyclopropylamino)-9H-purin-9-yl]cyclopent-2-en-1-yl]methanol; [(1R,4S)-4-[2-Amino-6-(cyclopropylamino)-9H-purin-9-yl]cyclopent-2-enyl]methanol; (1R,4S)-Abacavir;(1R-cis)-4-[2-Amino-6-(cyclopropylamino)-9H-purin-9-yl]-2-cyclopentene-1-methanol; ((1R,4S)-4-(2-amino-6-(cyclopropylamino)-9H-purin-9-yl)cyclopent-2-en-1-yl)methanol;

Molecular form: C14H18N6O
Appearance: Off-White to Pale Yellow Solid
Mol. Weight: 286.33
Storage: 2-8°C Refrigerator
Shipping Conditions: Ambient
Applications: ent-Abacavir (Abacavir EP Impurity A) is an enatiomer of Abacavir. Abacavir is a carbocyclic 2'-deoxyguanosine nucleoside reverse transcriptase inhibitor and an anti-HIV drug used to treat HIV infection (1). Intracellular enzymes convert Abacavir to its active form, carbovir-triphosphate (CBV-TP), which then selectively inhibits HIV reverse transcriptase by incorporating into viral DNA (2). Abacavir is metabolized in the liver by uridine diphosphate glucuronyltransferase and alcohol dehydrogenase resulting in inactive glucuronide and carboxylate metabolites, respectively.

[(1R,4S)-4-[2-Amino-6-(cyclopropylamino)-9H-purin-9- yl]cyclopent-2-en-1-yl]methanol

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