Abacavir Sulfate - Impurity B (Freebase)

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Catalogue number: PA 01 01020
Chemical name: 6-N-Cyclopropyl-9-[(1R,4S)-4-[[(2,5-diamino-6-chloro-4- pyrimidinyl)oxy]methyl]cyclopent-2-en-1-yl]-9H-purine-2,6- diamine

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Category: intermediates,impurities,metabolites,pharmaceutical standards,Fine Chemicals,bases and related reagents,nucleotides

Abacavir 5'-4-Chloro-6-methylpyrimidine-2,5-diamine; N6-Cyclopropyl-9-((1R,4S)-4-(((2,5-diamino-6-chloropyrimidin-4-yl)oxy)methyl)cyclopent-2-en-1-yl)-9H-purine-2,6-diamine; 6-(Cyclopropylamino)-9-[(1R,4S)-4-[[(2,5-diamino-6-chloropyrimidin-4-yl)oxy]methyl]cyclopent-2-enyl]-9H-purine-2-amine; O-Pyrimidine Derivative Abacavir; Abacavir Related Compound D (USP);

Molecular form: C18H21ClN10O
Appearance: NA
Mol. Weight: 428.88
Storage: 2-8°C Refrigerator
Shipping Conditions: Ambient
Applications: Abacavir EP Impurity B is a degradation product of Abacavir Sulfate. Abacavir is a carbocyclic 2'-deoxyguanosine nucleoside reverse transcriptase inhibitor and an anti-HIV drug used to treat HIV infection (1). Intracellular enzymes convert Abacavir to its active form, carbovir-triphosphate (CBV-TP), which then selectively inhibits HIV reverse transcriptase by incorporating into viral DNA (2). Abacavir is metabolized in the liver by uridine diphosphate glucuronyltransferase and alcohol dehydrogenase resulting in inactive glucuronide and carboxylate metabolites, respectively.

6-N-Cyclopropyl-9-[(1R,4S)-4-[[(2,5-diamino-6-chloro-4- pyrimidinyl)oxy]methyl]cyclopent-2-en-1-yl]-9H-purine-2,6- diamine

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