Abacavir Sulfate - Impurity D (Freebase)

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Catalogue number: PA 01 01041
Chemical name: [(1R,4R)-4-[2-amino-6-(cyclopropylamino)-9H-purin-9-yl]cyclopent-2-enyl]methanol

CAS Number:


Alternate CAS Number: 783292-37-5 (Relative Stereochemistry)
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Category: Fine Chemicals,pharmaceutical standards,intermediates

(1R,4R)-4-[2-Amino-6-(cyclopropylamino)-9H-purin-9-yl]-2-cyclopentene-1-methanol; trans-Abacavir; {(1R,4R)-4-[2-Amino-6-(cyclopropylamino)-9H-purin-9-yl]-cyclopent-2-enyl}methanol (USP);

Molecular form: C14H18N6O
Appearance: NA
Mol. Weight: 286.34
Storage: 2-8°C Refrigerator
Shipping Conditions: Ambient
Applications: (1R,​4R)​-​rel-4-​[2-Amino-​6-​(cyclopropylamino)​-​9H-​purin-​9-​yl]​-​2-​cyclopentene-​1-​methanol (Abacavir EP Impurity D) is an impurity of Abacavir). Abacavir is a carbocyclic 2’-deoxyguanosine nucleoside reverse transcriptase inhibitor and an anti-HIV drug used to treat HIV infection (1). Intracellular enzymes convert Abacavir to its active form, carbovir-triphosphate (CBV-TP), which then selectively inhibits HIV reverse transcriptase by incorporating into viral DNA (2). Abacavir is metabolized in the liver by uridine diphosphate glucuronyltransferase and alcohol dehydrogenase resulting in inactive glucuronide and carboxylate metabolites, respectively.


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