| Catalogue number: | PA 03 0061017 |
| Chemical name: | MC-SN38 |
CAS Number: |
1473403-87-0 |
| Category: | chiral standards,heterocycles,enzyme inhibitors,pharmaceutical standards,intermediates,Fine Chemicals,Antibody Drug Conjugate |
| Synonyms: | 1H-Pyrrole-1-hexanoic acid, 2,5-dihydro-2,5-dioxo-, (4S)-4,11-diethyl-3,4,12,14-tetrahydro-9-hydroxy-3,14-dioxo-1H-pyrano[3′,4′:6,7]indolizino[1,2-b]quinolin-4-yl ester; (4S)-4,11-Diethyl-3,4,12,14-tetrahydro-9-hydroxy-3,14-dioxo-1H-pyrano[3′,4′:6,7]indolizino[1,2-b]quinolin-4-yl 2,5-dihydro-2,5-dioxo-1H-pyrrole-1-hexanoate; (S)-4,11-diethyl-9-hydroxy-3,14-dioxo-3,4,12,14-tetrahydro-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinolin-4-yl 6-(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)hexanoate; |
| Molecular form: | C32H31N3O8 |
| Appearance: | NA |
| Mol. Weight: | 585.61 |
| Storage: | 2-8°C Refrigerator |
| Shipping Conditions: | Ambient |
| Applications: | MC-SN38 is a agent-linker conjugate composed of a potent microtubule-disrupting agent SN38 and a non-cleavable MC linker to make antibody agent conjugate (ADC). SN-38, an active metabolite of the Topoisomerase I inhibitor Irinotecan, inhibits DNA synthesis and causes frequent DNA single-strand breaks |
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