| Catalogue number: | PA 04 3191002 |
| Chemical name: | (S)-Seco-Duocarmycin SA |
CAS Number: |
152785-82-5 |
| Category: | Fine Chemicals,pharmaceutical standards,Intermediates,Antibody Drug Conjugate |
| Synonyms: | Methyl (S)-8-(chloromethyl)-4-hydroxy-6-(5,6,7-trimethoxy-1H-indole-2-carbonyl)-3,6,7,8-tetrahydropyrrolo[3,2-e]indole-2-carboxylate; Benzo[1,2-b:4,3-b′]dipyrrole-2-carboxylic acid, 8-(chloromethyl)-3,6,7,8-tetrahydro-4-hydroxy-6-[(5,6,7-trimethoxy-1H-indol-2-yl)carbonyl]-, methyl ester, (8S)-; Benzo[1,2-b:4,3-b′]dipyrrole-2-carboxylic acid, 8-(chloromethyl)-3,6,7,8-tetrahydro-4-hydroxy-6-[(5,6,7-trimethoxy-1H-indol-2-yl)carbonyl]-, methyl ester, (S)-; Methyl (8S)-8-(chloromethyl)-3,6,7,8-tetrahydro-4-hydroxy-6-[(5,6,7-trimethoxy-1H-indol-2-yl)carbonyl]benzo[1,2-b:4,3-b′]dipyrrole-2-carboxylate; |
| Molecular form: | C25H24ClN3O7 |
| Appearance: | Solid |
| Mol. Weight: | 513.93 |
| Storage: | 2-8°C Refrigerator |
| Shipping Conditions: | Ambient |
| Applications: | (S)-Seco-Duocarmycin SA is the S-enantiomer of Seco-Duocarmycin SA (HY-129356). Seco-Duocarmycin SA is a DNA alkylating agent. Seco-Duocarmycin SA is an antitumor antibiotic (IC50 = 10 pM). Seco-Duocarmycin SA can induce a concentration-dependent increase in apoptotic cell death. Seco-Duocarmycin SA can lead to significant cell cycle arrest in S and G2/M phases. Seco-Duocarmycin SA acts as an ADC cytotoxin for antibody-drug conjugates |
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