| Catalogue number: | PA STI 004770 |
| Chemical name: | 17-(Allylamino-d5) Geldanamycin |
CAS Number: |
NA |
| Category: | amines,heterocycles,enzyme inhibitors,pharmaceutical standards,intermediates,Fine Chemicals,stable isotopes |
| Synonyms: | 17-Demethoxy-17-(2-propenylamino-d5)geldanamycin; 17-(Allylamino-d5)-17-demethoxygeldanamycin; 17-(Allylamino-d5)-17-desmethylgeldanamycin; 17-Demethoxy-17-(allylamino-d5)geldanamycin; 17AAG-d5; CP 127374-d5; KOS 953-d5; NSC 330507-d5; Tanespimycin-d5; (4E,6Z,8S,9S,10E,12S,13R,14S,16R)-19-((allyl-d5)amino)-13-hydroxy-8,14-dimethoxy-4,10,12,16-tetramethyl-3,20,22-trioxo-2-azabicyclo[16.3.1]docosa-1(21),4,6,10,18-pentaen-9-yl carbamate; |
| Molecular form: | C31H38D5N3O8 |
| Appearance: | Dark Purple Solid |
| Mol. Weight: | 590.72 |
| Storage: | 2-8°C Refrigerator, Under Inert Atmosphere |
| Shipping Conditions: | Ambient |
| Applications: | Potent inhibitor of heat shock protein 90 (Hsp90). 17-AAG is a less toxic analog than Geldanamycin. It induces apoptosis and displays antitumor effects. 17-AAG inhibits the activity of oncogenic proteins such as N-ras, Ki-ras, c-Akt, and p185erB2. |
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