| Catalogue number: | PA STI 088196 |
| Chemical name: | Genistein-2',3',5',6'-d4 (Major) |
CAS Number: |
187960-08-3 |
| Category: | enzyme inhibitors,tyrosine kinase inhibitors,stable isotopes |
| Synonyms: | Baichanin A-d4; Bonistein-d4; 4',5,7-Trihydroxyisoflavone-d4; GeniVida-d4; Genisteol-d4; Prunetol-d4; Sophoricol-d4; 5,7-Dihydroxy-3-(4-hydroxyphenyl-2,3,5,6-d4)-4H-1-benzopyran-4-one; 4H-1-Benzopyran-4-one, 5,7-dihydroxy-3-(4-hydroxyphenyl-2,3,5,6-d4)-; |
| Molecular form: | C15H6D4O5 |
| Appearance: | Yellow Solid |
| Mol. Weight: | 274.26 |
| Storage: | 2-8°C Refrigerator |
| Shipping Conditions: | Ambient |
| Applications: | Exhibits specific inhibitory activity against tyrosine kinases,including autophosphorylation of epidermal growth factor receptor kinase (IC50 - 2.6uM). Also inhibits other protein kinases through competitive inhibition of ATP. Inhibits tumor cell proliferation and induces tumor cell differentiation. Produces cell-cycle arrest and apoptosis in Jurat T-leukemia cells. However, it prevents anti-CD3 monoclonal antibody-induced thymic apoptosis. Genistein also inhibits topoisomerase II activity in vitro. Genistein has also been shown to inhibit the action of GABA on recombinant GABAA receptors2. uv(max)ethanol: 262.5 nm (e= 138). moderately sol. in hot alcohol |
Genistein-2',3',5',6'-d4 (Major)
Genistein-2',3',5',6'-d4 (Major)
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