| Catalogue number: | PA STI 088195 |
| Chemical name: | Genistein-2',6'-d2 |
CAS Number: |
315204-48-9 |
| Category: | enzyme inhibitors,stable isotopes,tyrosine kinase inhibitors |
| Synonyms: | 5,7-Dihydroxy-3-(4-hydroxyphenyl)-4H-1-benzopyran-4-one-d2; Baichanin A-d2; Bonistein-d2; 4',5,7-Trihydroxyisoflavone-d2; GeniVida-d2; Genisteol-d2; NSC 36586-d2; Prunetol-d2; Sophoricol-d2; 4H-1-Benzopyran-4-one, 5,7-dihydroxy-3-(4-hydroxyphenyl-3,5-d2); |
| Molecular form: | C15H8D2O5 |
| Appearance: | Pale Yellow Solid |
| Mol. Weight: | 272.25 |
| Storage: | 2-8°C Refrigerator |
| Shipping Conditions: | Ambient |
| Applications: | Exhibits specific inhibitory activity against tyrosine kinases,including autophosphorylation of epidermal growth factor receptor kinase (IC50 - 2.6uM). Also inhibits other protein kinases through competitive inhibition of ATP. Inhibits tumor cell proliferation and induces tumor cell differentiation. Produces cell-cycle arrest and apoptosis in Jurat T-leukemia cells. However, it prevents anti-CD3 monoclonal antibody-induced thymic apoptosis. Genistein also inhibits topoisomerase II activity in vitro. Genistein has also been shown to inhibit the action of GABA on recombinant GABAA receptors2. uv(max)ethanol: 262.5 nm (e= 138). moderately sol. in hot alcohol. |
Genistein-2',6'-d2
Genistein-2',6'-d2
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