Catalogue number: | PA 05 0721000 |
Chemical name: | Epothilone D (synthetic) |
CAS Number: |
189453-10-9 |
Category: | enzyme activators,enzyme inhibitors,pharmaceutical standards,impurities,metabolites,fine chemicals |
Synonyms: | (4S,7R,8S,9S,16S,Z)-4,8-Dihydroxy-5,5,7,9,13-pentamethyl-16-((E)-1-(2-methylthiazol-4-yl)prop-1-en-2-yl)oxacyclohexadec-13-ene-2,6-dione; |
Molecular form: | C27H41NO5S |
Appearance: | White Solid |
Mol. Weight: | 491.69 |
Storage: | 2-8°C Refrigerator |
Shipping Conditions: | Ambient |
Applications: | Epothilones are polyketide natural products that inhibit cancer cells by a mechanism similar to paclitaxel, and also are effective against paclitaxel-resistant tumours. Epothilone D is in phase I clinical testing of in patients with advanced solid tumours. Epothilone D is a cytotoxic macrolide that stabilises malignant cells' microtubules and arrests mitosis, a characteristic it shares with other epothilones. They bind to the same hepatic sites as does paclitaxel (Taxol) in a 1:1 stoichiometric ratio of a, b-tubulin heterodimers. |
BTM: | NA |
Epothilone D
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