| Catalogue number: | PAI 02 079001 |
| Chemical name: | Pyrazine-2-carbonyl Chloride |
CAS Number: |
19847-10-0 |
| Category: | intermediates |
| Synonyms: | 2-Pyrazinecarbonyl chloride; Pyrazinecarbonyl chloride; Pyrazinoyl chloride; Pyrazine-2-carboxylic acid chloride; Pyrazinoic Acid Chloride; |
| Molecular form: | C5H3ClN2O |
| Appearance: | NA |
| Mol. Weight: | 142.54 |
| Storage: | 2-8°C Refrigerator |
| Shipping Conditions: | Ambient |
| Applications: | 2-Pyrazinecarbonyl Chloride is an intermediate used in the synthesis of (S)-N-[1-(3-Hydroxy-3-methylbutanamido)-1-oxo-3-phenylpropan-2yl]pyrazine-2-carboxamide, which is an impurity of bortezomib, which is the first proteasome inhibitor to be approved by the US FDA for multiple myeloma, a blood cancer. A reversible inhibitor of the 26S proteasome-a barrel-shaped multiprotein particle found in the nucleus and cytosol of all eukaryotic cells. Targets the ubiquitin-proteasome pathway. |
Pyrazine-2-carbonyl Chloride
Pyrazine-2-carbonyl Chloride
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