bortezomib and its Impurities
Bortezomib was approved for medical use in the United States in 2003 and in Europe in 2004. Bortezomib, sold under the brand name Velcade among others, is an anti-cancer medication used to treat multiple myeloma and mantle cell lymphoma.. Reference standards of Bortezomib API, and its pharmacopeial, non pharmacopeial impurities, and stable isotopes are listed below


N-(1-((1-(3a,5-Dimethylhexahydro-4,6-methanobenzo[d][1,3,2]dioxaborol-2-yl)-3-methylbutyl)amino)-1-oxo-3-phenylpropan-2-yl)pyrazine-2-carboxamide
N-(1-((1-(3a,5-Dimethylhexahydro-4,6-methanobenzo[d][1,3,2]dioxaborol-2-yl)-3-methylbutyl)amino)-1-oxo-3-phenylpropan-2-yl)pyrazine-2-carboxamide
Catalogue No.:PA 02 79600
CAS :
NA
Molecular Formula : C28H37BN4O4
Molecular Weight : 504.43


N-((2S)-1-((1-Hydroxy-3-methylbutyl)amino)-1-oxo-3-phenylpropan-2-yl)pyrazine-2-carboxamide
N-((2S)-1-((1-Hydroxy-3-methylbutyl)amino)-1-oxo-3-phenylpropan-2-yl)pyrazine-2-carboxamide
Catalogue No.:PA 02 79620
CAS :
1788087-64-8
Molecular Formula : C19H24N4O3
Molecular Weight : 356.42


((R)-3-Methyl-1-((S)-3-phenyl-2-((R)-3-phenyl-2-(pyrazine-2-carboxamido)propanamido)propanamido)butyl)boronic Acid
((R)-3-Methyl-1-((S)-3-phenyl-2-((R)-3-phenyl-2-(pyrazine-2-carboxamido)propanamido)propanamido)butyl)boronic Acid
Catalogue No.:PA 02 79680
CAS :
NA
Molecular Formula : C28H34BN5O5
Molecular Weight : 531.41


(1R)-(1S,2S,3R,5S)-Pinanediol-N-(N-pyrazinylphenylalaninoyl)-1-amino-3-methyl-butane-1-boronate
(1R)-(1S,2S,3R,5S)-Pinanediol-N-(N-pyrazinylphenylalaninoyl)-1-amino-3-methyl-butane-1-boronate
Catalogue No.:PA 02 79700
CAS :
205393-22-2
Molecular Formula : C29H39BN4O4
Molecular Weight : 518.46


(1R)-(1S,2S,3R,5S)-Pinanediol-N-(N-pyrazinylphenylalaninoyl)-1-amino-3-methylbutane-1-boronate-d8
(1R)-(1S,2S,3R,5S)-Pinanediol-N-(N-pyrazinylphenylalaninoyl)-1-amino-3-methylbutane-1-boronate-d8
Catalogue No.:PA STI 073740
CAS :
NA
Molecular Formula : C29H31D8BN4O4
Molecular Weight : 526.50


N-((S)-1-(((R)-1-Hydroperoxy-3-methylbutyl)amino)-1-oxo-3-phenylpropan-2-yl)pyrazine-2-carboxamide compound with N-((S)-1-(((S)-1-hydroperoxy-3-methylbutyl)amino)-1-oxo-3-phenylpropan-2-yl)pyrazine-2-carboxamide (1:1)
N-((S)-1-(((R)-1-Hydroperoxy-3-methylbutyl)amino)-1-oxo-3-phenylpropan-2-yl)pyrazine-2-carboxamide compound with N-((S)-1-(((S)-1-hydroperoxy-3-methylbutyl)amino)-1-oxo-3-phenylpropan-2-yl)pyrazine-2-carboxamide (1:1)
Catalogue No.:PA 02 79730
CAS :
NA
Molecular Formula : C19H24N4O4
Molecular Weight : 372.43


N-((S)-1-(((R)-1-Hydroxy-3-methylbutyl)amino)-1-oxo-3-phenylpropan-2-yl)pyrazine-2-carboxamide compound with N-((S)-1-(((S)-1-hydroxy-3-methylbutyl)amino)-1-oxo-3-phenylpropan-2-yl)pyrazine-2-carboxamide (1:1)
N-((S)-1-(((R)-1-Hydroxy-3-methylbutyl)amino)-1-oxo-3-phenylpropan-2-yl)pyrazine-2-carboxamide compound with N-((S)-1-(((S)-1-hydroxy-3-methylbutyl)amino)-1-oxo-3-phenylpropan-2-yl)pyrazine-2-carboxamide (1:1)
Catalogue No.:PA 02 79740
CAS :
NA
Molecular Formula : C19H24N4O3
Molecular Weight : 356.43


(αR)-(1S,2S,3R,5S)-Pinanediol-1-amino-3-methylbutane-1-boronate Trifluoroacetic Acid Salt
(αR)-(1S,2S,3R,5S)-Pinanediol-1-amino-3-methylbutane-1-boronate Trifluoroacetic Acid Salt
Catalogue No.:PA 02 79750
CAS :
179324-87-9
Molecular Formula : C17H29BF3NO4
Molecular Weight : 379.23


N-((2S)-1-(((1R)-1-(2-Hydroxypropoxy)-3-methylbutyl)amino)-1-oxo-3-phenylpropan-2-yl)pyrazine-2-carboxamide
N-((2S)-1-(((1R)-1-(2-Hydroxypropoxy)-3-methylbutyl)amino)-1-oxo-3-phenylpropan-2-yl)pyrazine-2-carboxamide
Catalogue No.:PA 02 79780
CAS :
NA
Molecular Formula : C22H30N4O4
Molecular Weight : 414.51


N-((2S)-1-(((1S)-1-(2-Hydroxypropoxy)-3-methylbutyl)amino)-1-oxo-3-phenylpropan-2-yl)pyrazine-2-carboxamide
N-((2S)-1-(((1S)-1-(2-Hydroxypropoxy)-3-methylbutyl)amino)-1-oxo-3-phenylpropan-2-yl)pyrazine-2-carboxamide
Catalogue No.:PA 02 79790
CAS :
NA
Molecular Formula : C22H30N4O4
Molecular Weight : 414.51


N-((2R)-1-(((1S)-1-(2-Hydroxypropoxy)-3-methylbutyl)amino)-1-oxo-3-phenylpropan-2-yl)pyrazine-2-carboxamide
N-((2R)-1-(((1S)-1-(2-Hydroxypropoxy)-3-methylbutyl)amino)-1-oxo-3-phenylpropan-2-yl)pyrazine-2-carboxamide
Catalogue No.:PA 02 79800
CAS :
NA
Molecular Formula : C22H30N4O4
Molecular Weight : 414.51


N-((2R)-1-(((1R)-1-(2-Hydroxypropoxy)-3-methylbutyl)amino)-1-oxo-3-phenylpropan-2-yl)pyrazine-2-carboxamide
N-((2R)-1-(((1R)-1-(2-Hydroxypropoxy)-3-methylbutyl)amino)-1-oxo-3-phenylpropan-2-yl)pyrazine-2-carboxamide
Catalogue No.:PA 02 79810
CAS :
NA
Molecular Formula : C22H30N4O4
Molecular Weight : 414.51


(αS)-α-Amino-N-[(1R)-1-[(3aS,4S,6S,7aR)-hexahydro-3a,5,5-trimethyl-4,6-methano-1,3,2-benzodioxaborol-2-yl]-3-methylbutyl]-benzenepropanamide Monohydrochloride
(αS)-α-Amino-N-[(1R)-1-[(3aS,4S,6S,7aR)-hexahydro-3a,5,5-trimethyl-4,6-methano-1,3,2-benzodioxaborol-2-yl]-3-methylbutyl]-benzenepropanamide Monohydrochloride
Catalogue No.:PA 02 79840
CAS :
205393-21-1
Molecular Formula : C23H36BClN2O3
Molecular Weight : 434.81


N-[(1S)-2-[[(1R)-1-[(3aS,4S,6S,7aR)-hexahydro-3a,5,5-trimethyl-4,6-methano-1,3,2-benzodioxaborol-2-yl]-3-methylbutyl]amino]-2-oxo-1-(phenylmethyl)ethyl]-carbamic acid 1,1-dimethylethyl ester
N-[(1S)-2-[[(1R)-1-[(3aS,4S,6S,7aR)-hexahydro-3a,5,5-trimethyl-4,6-methano-1,3,2-benzodioxaborol-2-yl]-3-methylbutyl]amino]-2-oxo-1-(phenylmethyl)ethyl]-carbamic acid 1,1-dimethylethyl ester
Catalogue No.:PA 02 0791011
CAS :
1187479-72-6
Molecular Formula : C29H45BN2O5
Molecular Weight : 512.5


N-((S)-1-(((R)-1-((R)-2-Hydroxypropoxy)-3-methylbutyl)amino)-1-oxo-3-phenylpropan-2-yl)pyrazine-2-carboxamide
N-((S)-1-(((R)-1-((R)-2-Hydroxypropoxy)-3-methylbutyl)amino)-1-oxo-3-phenylpropan-2-yl)pyrazine-2-carboxamide
Catalogue No.:PA 02 0791012
CAS :
NA
Molecular Formula : C22H30N4O4
Molecular Weight : 414.51


N-((S)-1-(((R)-1-((S)-2-Hydroxypropoxy)-3-methylbutyl)amino)-1-oxo-3-phenylpropan-2-yl)pyrazine-2-carboxamide
N-((S)-1-(((R)-1-((S)-2-Hydroxypropoxy)-3-methylbutyl)amino)-1-oxo-3-phenylpropan-2-yl)pyrazine-2-carboxamide
Catalogue No.:PA 02 0791013
CAS :
NA
Molecular Formula : C22H30N4O4
Molecular Weight : 414.51


((S)-3-Hydroxy-3-methyl-1-((S)-3-phenyl-2-(pyrazine-2-carboxamido)propanamido)butyl)boronic acid
((S)-3-Hydroxy-3-methyl-1-((S)-3-phenyl-2-(pyrazine-2-carboxamido)propanamido)butyl)boronic acid
Catalogue No.:PA 02 0791016
CAS :
NA
Molecular Formula : C19H25BN4O5
Molecular Weight : 400.24


(3aS,4S,6S,7aR)-2-((S)-1-Chloro-2-methylpropyl)-3a,5,5-trimethylhexahydro-4,6-methanobenzo[d][1,3,2]dioxaborole
(3aS,4S,6S,7aR)-2-((S)-1-Chloro-2-methylpropyl)-3a,5,5-trimethylhexahydro-4,6-methanobenzo[d][1,3,2]dioxaborole
Catalogue No.:PA 02 0791017
CAS :
89618-77-9
Molecular Formula : C14H24BClO2
Molecular Weight : 270.6


(R)-2-Methyl-1-((3aS,4S,6S,7aR)-3a,5,5-trimethylhexahydro-4,6-methanobenzo[d][1,3,2]dioxaborol-2-yl)propan-1-amine 2,2,2-trifluoroacetate
(R)-2-Methyl-1-((3aS,4S,6S,7aR)-3a,5,5-trimethylhexahydro-4,6-methanobenzo[d][1,3,2]dioxaborol-2-yl)propan-1-amine 2,2,2-trifluoroacetate
Catalogue No.:PA 02 0791018
CAS :
94242-81-6
Molecular Formula : C16H27BF3NO4
Molecular Weight : 365.2


(3aR,4R,6R,7aS)-2-((R)-1-Chloro-2-methylpropyl)-3a,5,5-trimethylhexahydro-4,6-methanobenzo[d][1,3,2]dioxaborole
(3aR,4R,6R,7aS)-2-((R)-1-Chloro-2-methylpropyl)-3a,5,5-trimethylhexahydro-4,6-methanobenzo[d][1,3,2]dioxaborole
Catalogue No.:PA 02 0791019
CAS :
1569265-85-5
Molecular Formula : C14H24BClO2
Molecular Weight : 270.6


((R)-3-Methyl-1-((R)-3-phenyl-2-((R)-3-phenyl-2-(pyrazine-2-carboxamido)propanamido)propanamido)butyl)boronic acid
((R)-3-Methyl-1-((R)-3-phenyl-2-((R)-3-phenyl-2-(pyrazine-2-carboxamido)propanamido)propanamido)butyl)boronic acid
Catalogue No.:PA 02 0791021
CAS :
NA
Molecular Formula : C28H34BN5O5
Molecular Weight : 531.42


N-((R)-1-(((R)-3-Methyl-1-((3aS,4S,6S,7aR)-3a,5,5-trimethylhexahydro-4,6-methanobenzo[d][1,3,2]dioxaborol-2-yl)butyl)amino)-1-oxo-3-phenylpropan-2-yl)pyrazine-2-carboxamide
N-((R)-1-(((R)-3-Methyl-1-((3aS,4S,6S,7aR)-3a,5,5-trimethylhexahydro-4,6-methanobenzo[d][1,3,2]dioxaborol-2-yl)butyl)amino)-1-oxo-3-phenylpropan-2-yl)pyrazine-2-carboxamide
Catalogue No.:PA 02 0791022
CAS :
1375004-39-9
Molecular Formula : C29H39BN4O4
Molecular Weight : 518.47


N-(1-((3-Methyl-1-(3a,5,5-trimethylhexahydro-4,6-methanobenzo[d][1,3,2]dioxaborol-2-yl)butyl)amino)-1-oxo-3-phenylpropan-2-yl)pyrazine-2-carboxamide
N-(1-((3-Methyl-1-(3a,5,5-trimethylhexahydro-4,6-methanobenzo[d][1,3,2]dioxaborol-2-yl)butyl)amino)-1-oxo-3-phenylpropan-2-yl)pyrazine-2-carboxamide
Catalogue No.:PA 02 0791024
CAS :
NA
Molecular Formula : C29H39BN4O4
Molecular Weight : 518.47


1,1,1-Trimethyl-N-((R)-3-methyl-1-((3aS,4S,6S,7aR)-3a,5,5-trimethylhexahydro-4,6-methanobenzo[d][1,3,2]dioxaborol-2-yl)butyl)-N-(trimethylsilyl)silanamine
1,1,1-Trimethyl-N-((R)-3-methyl-1-((3aS,4S,6S,7aR)-3a,5,5-trimethylhexahydro-4,6-methanobenzo[d][1,3,2]dioxaborol-2-yl)butyl)-N-(trimethylsilyl)silanamine
Catalogue No.:PA 02 0791030
CAS :
514820-48-5
Molecular Formula : C21H44BNO2Si2
Molecular Weight : 409.57


N-((R)-1-(((S)-1-Hydroperoxy-3-methylbutyl)amino)-1-oxo-3-phenylpropan-2-yl)pyrazine-2-carboxamide
N-((R)-1-(((S)-1-Hydroperoxy-3-methylbutyl)amino)-1-oxo-3-phenylpropan-2-yl)pyrazine-2-carboxamide
Catalogue No.:PA 02 0791031
CAS :
NA
Molecular Formula : C19H24N4O4
Molecular Weight : 372.43


 1,1,1-Trimethyl-N-((R)-2-methyl-1-((3aS,4S,6S,7aR)-3a,5,5-trimethylhexahydro-4,6-methanobenzo[d][1,3,2]dioxaborol-2-yl)propyl)-N-(trimethylsilyl)silanamine
1,1,1-Trimethyl-N-((R)-2-methyl-1-((3aS,4S,6S,7aR)-3a,5,5-trimethylhexahydro-4,6-methanobenzo[d][1,3,2]dioxaborol-2-yl)propyl)-N-(trimethylsilyl)silanamine
Catalogue No.:PA 02 0791032
CAS :
94242-79-2
Molecular Formula : C20H42BNO2Si2
Molecular Weight : 395.54


(3aS,4S,6S,7aR)-2-((S)-1-Chloro-3-methylbutyl)-3a,5,5-trimethylhexahydro-4,6-methanobenzo[d][1,3,2]Dioxaborole
(3aS,4S,6S,7aR)-2-((S)-1-Chloro-3-methylbutyl)-3a,5,5-trimethylhexahydro-4,6-methanobenzo[d][1,3,2]Dioxaborole
Catalogue No.:PA 02 0791034
CAS :
85167-14-2
Molecular Formula : C15H26BClO2
Molecular Weight : 284.63


rel-(R)-3-Methyl-1-((3aS,4R,6R,7aR)-3a,5,5-trimethylhexahydro-4,6-methanobenzo[d][1,3,2]dioxaborol-2-yl)butan-1-amine 2,2,2-trifluoroacetate
rel-(R)-3-Methyl-1-((3aS,4R,6R,7aR)-3a,5,5-trimethylhexahydro-4,6-methanobenzo[d][1,3,2]dioxaborol-2-yl)butan-1-amine 2,2,2-trifluoroacetate
Catalogue No.:PA 02 0791043
CAS :
1310383-72-2
Molecular Formula : C17H29BF3NO4
Molecular Weight : 379.23


N-((R)-1-(((R)-1-Hydroperoxy-3-methylbutyl)amino)-1-oxo-3-phenylpropan-2-yl)pyrazine-2-carboxamide
N-((R)-1-(((R)-1-Hydroperoxy-3-methylbutyl)amino)-1-oxo-3-phenylpropan-2-yl)pyrazine-2-carboxamide
Catalogue No.:PA 02 0791045
CAS :
NA
Molecular Formula : C19H24N4O4
Molecular Weight : 372.43


(S)-2-Methyl-N-((S)-3-methyl-1-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)butyl)propane-2-sulfinamide
(S)-2-Methyl-N-((S)-3-methyl-1-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)butyl)propane-2-sulfinamide
Catalogue No.:PA 02 0791047
CAS :
NA
Molecular Formula : C15H32BNO3S
Molecular Weight : 317.3