| Catalogue number: | PA 40 0421002 |
| Chemical name: | DM4-SMe |
CAS Number: |
796073-68-2 |
| Category: | amines,aromatics,heterocycles,pharmaceutical standards,intermediates,Fine Chemicals,sulphur and selenium compounds,Antibody Drug Conjugate |
| Synonyms: | (14S,16S,32S,33S,2R,4S,10E,12E,14R)-86-chloro-14-hydroxy-85,14-dimethoxy-33,2,7,10-tetramethyl-12,6-dioxo-7-aza-1(6,4)-oxazinana-3(2,3)-oxirana-8(1,3)-benzenacyclotetradecaphane-10,12-dien-4-yl N-methyl-N-(4-methyl-4-(methyldisulfaneyl)pentanoyl)-L-alaninate; Maytansine, N2′-deacetyl-N2′-[4-methyl-4-(methyldithio)-1-oxopentyl]-; |
| Molecular form: | C39H56ClN3O10S2 |
| Appearance: | Solid |
| Mol. Weight: | 826.46 |
| Storage: | 2-8°C Refrigerator |
| Shipping Conditions: | Ambient |
| Applications: | DM4-SMe is a metabolite of antibody-maytansin conjugates (AMCs) and a tubulin inhibitor, and also a cytotoxic moiety of antibody-drug conjugates (ADCs), which can be linked to antibody through disulfide bond or stable thioether bond. DM4-SMe inhibits KB cells with an IC50 of 0.026 nM |
DM4-SMe
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