Abacavir Sulfate - Impurity E (Freebase)

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Catalogue number: PA 01 01050
Chemical name: [(1R,4S)-3-[2-Amino-6-(cyclopropylamino)-9H-purin-9- yl]cyclopentyl]methanol

CAS Number:


Category: intermediates,impurities,pharmaceutical standards,enzyme inhibitors,Fine Chemicals,bases and related reagents,nucleotides

Dihydro Abacavir; [(1R,3S)-3-[2-Amino-6-(cyclopropylamino)-9H-purin-9-yl]cyclopentyl] methanol; (1R,3S)-3-[2-Amino-6-(cyclopropylamino)-9H-purin-9-yl]cyclopentanemethanol; ((1R,3S)-3-(2-amino-6-(cyclopropylamino)-9H-purin-9-yl)cyclopentyl)methanol;

Molecular form: C14H20N6O
Appearance: Off-White Solid
Mol. Weight: 288.35
Storage: 2-8°C Refrigerator
Shipping Conditions: Ambient
Applications: Abacavir is a carbocyclic 2'-deoxyguanosine nucleoside reverse transcriptase inhibitor and an anti-HIV drug used to treat HIV infection (1). Intracellular enzymes convert Abacavir to its active form, carbovir-triphosphate (CBV-TP), which then selectively inhibits HIV reverse transcriptase by incorporating into viral DNA (2). Abacavir is metabolized in the liver by uridine diphosphate glucuronyltransferase and alcohol dehydrogenase resulting in inactive glucuronide and carboxylate metabolites, respectively.

[(1R,4S)-3-[2-Amino-6-(cyclopropylamino)-9H-purin-9- yl]cyclopentyl]methanol

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