| Catalogue number: | PA 03 0061042 |
| Chemical name: | MAC glucuronide α-hydroxy lactone-linked SN-38 |
CAS Number: |
2246380-70-9 |
| Category: | pharmaceutical standards,Intermediates,Fine Chemicals,Antibody Drug Conjugate |
| Synonyms: | (2S,3S,4S,5R,6S)-6-(4-(((((((S)-4,11-Diethyl-9-hydroxy-3,14-dioxo-3,4,12,14-tetrahydro-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinolin-4-yl)oxy)methyl)(2-(methylsulfonyl)ethyl)carbamoyl)oxy)methyl)-2-(2-(3-(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)-N-methylpropanamido)acetamido)phenoxy)-3,4,5-trihydroxytetrahydro-2H-pyran-2-carboxylic Acid; β-D-Glucopyranosiduronic acid, 4-[[[[[[[(4S)-4,11-diethyl-3,4,12,14-tetrahydro-9-hydroxy-3,14-dioxo-1H-pyrano[3′,4′:6,7]indolizino[1,2-b]quinolin-4-yl]oxy]methyl][2-(methylsulfonyl)ethyl]amino]carbonyl]oxy]methyl]-2-[[2-[[3-(2,5-dihydro-2,5-dioxo-1H-pyrrol-1-yl)-1-oxopropyl]methylamino]acetyl]amino]phenyl; |
| Molecular form: | C50H54N6O20S |
| Appearance: | Solid |
| Mol. Weight: | 1091.06 |
| Storage: | 2-8°C Refrigerator |
| Shipping Conditions: | Ambient |
| Applications: | MAC glucuronide α-hydroxy lactone-linked SN-38 (Topoisomerase I inhibitor) is a stabilized lactone MAC glucuronide α-hydroxy lactone-linked SN-38 agent linker. MAC glucuronide α-hydroxy lactone-linked SN-38 is cytotoxic across L540cy cells and Ramos cells with IC50 values of 99 and 105 ng/mL, respectively |
MAC glucuronide α-hydroxy lactone-linked SN-38
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