| Catalogue number: | PA 05 1991016 |
| Chemical name: | Gly-Cyclopropane-Exatecan |
CAS Number: |
2414254-49-0 |
| Category: | Fine Chemicals,pharmaceutical standards,metabolites,impurities,intermediates,Antibody Drug Conjugate |
| Synonyms: | 2-((2-Aminoacetamido)methoxy)-2-cyclopropyl-N-((1S,9S)-9-ethyl-5-fluoro-9-hydroxy-4-methyl-10,13-dioxo-2,3,9,10,13,15-hexahydro-1H,12H-benzo[de]pyrano[3',4':6,7]indolizino[1,2-b]quinolin-1-yl)acetamide; Cyclopropaneacetamide, α-[[(2-aminoacetyl)amino]methoxy]-N-[(1S,9S)-9-ethyl-5-fluoro-2,3,9,10,13,15-hexahydro-9-hydroxy-4-methyl-10,13-dioxo-1H,12H-benzo[de]pyrano[3′,4′:6,7]indolizino[1,2-b]quinolin-1-yl]-; α-[[(2-Aminoacetyl)amino]methoxy]-N-[(1S,9S)-9-ethyl-5-fluoro-2,3,9,10,13,15-hexahydro-9-hydroxy-4-methyl-10,13-dioxo-1H,12H-benzo[de]pyrano[3′,4′:6,7]indolizino[1,2-b]quinolin-1-yl]cyclopropaneacetamide; |
| Molecular form: | C32H34FN5O7 |
| Appearance: | NA |
| Mol. Weight: | 619.65 |
| Storage: | 2-8°C Refrigerator |
| Shipping Conditions: | Ambient |
| Applications: | Gly-Cyclopropane-Exatecan involves in the synthesis of anti-B7-H4 ADC, containing Exatecan (HY-13631), a DNA Topoisomerase I inhibitor. Gly-Cyclopropane-Exatecan participated in the formation of the ADC hu2F7-Exatecan (compound 34), which showed antitumor activity in vivo and in vitro |
Gly-Cyclopropane-Exatecan
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